Liver Problems Flashcards

1
Q

What are the functions of the liver?

A
  • Produces essential proteins including albumin and clotting factor
  • Absorption and metabolism of fat, carbahydrate and protein
  • Storage of glycogen, vitamins and minerals
  • Metabolism and excretion of toxic products in the body
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is included in LFTs

A
  • Bilirubin (total and split)
  • ALT/AST
  • Alkaline phosphatase
  • Gamma glutamyl transferase (GGT)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

When is ALT/AST elevated?

A

In hepatocellular damage (hepatitis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

When are alkaline phosphatase and GGT elevated?

A

Biliary disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What tests are used to assess the function of the liver?

A
  • Coagualtion - best test for liver function
    • prothrombin time (PT) / INR
    • APTT
  • Albumin
  • Bilirubin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How can paediatric liver disease manifest?

A
  • Jaundicece - usually most obvious in sclera
  • Incidental finding of abnormal blood test
  • Symptoms/signs of chronic liver disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the signs of chronic liver disease in children?

A
  • Encephalopathy
  • Jaundice
  • Cholestasis
  • Ascites
  • Rickets secondary to vit D deficiency
  • Varices with portal hypertension
  • Spleomegaly
  • Finger clubbing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is jaundice?

A

-Yellow discolouration of skin and tissues due to accumulation of bilirubin -Usually most obvious in sclera

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When is jaundice usually visible?

A

Total bilirubin >40-50umol/l

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is diagnosis of infant jaundice dependent on?

A

-Bilirubin metabolism -Age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How is bilirubin metabolised?

A

-Post mature RBC broken down in the reticuloendothelial system to bilveridan -Converted to unconjugated bilirubin -Bound to albumin and conjugated in the liver -Mixes with bile in gallbladder and enters small intestine -Coverted to urobilinogen and excreted by the kidneys as urine or in faeces

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the solubility of conjugated bilirubin?

A

-Water soluble -Fat insoluble

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the solubility of unconjugated bilirubin?

A

-Fat soluble -Water insoluble

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

When does pre-hepatic jaundice occur?

A

Excess of unconjugated birlirubin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

When does intrahepatic jaundice occur?

A

-Excess of conjugated and unconjugated bilirubin jaundice due to issue within the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When does post-hepatic jaundice occur?

A

Excess of conjugated bilirubin normally due obstruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is early neonatal jaundice?

A

-<24 hours old -ALWAYS PATHOLOGICAL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What can cause early neonatal jaundice?

A

-Haemolysis -Sepsis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is intermediate neonatal jaundice?

A

Occurs between 24hours and 2 weeks of age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What can cause intermediate neonatal jaundice?

A

-Physiological -Breast milk -Sepsis -Haemolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is prolonged neonatal jaundice?

A

Occurs after 2 weeks of age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What can cause prolonged neonatal jaundice?

A

-Extrahepatic obstruction -Neonatal hepatitis -Hypothyroidism -Breast milk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Why does physiological jaundice occur?

A

-Shorter RBC life span in infants (80-90 days) -Relative polycythaemia -Relative immaturity of liver function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What type of jaundice is physiological jaundice?

A

Unconjugated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

When does physiological jaundice occur?

A

After the 1st day of life as it takes time for RBC to break down

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Why does jaundice occur with breast fed babies?

A

-Exact reason for prolongation of jaundice in breastfed infants unclear -Inhibition of UDP by progesterone metabolite? -Increased enterohepatic circulation?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What type of jaundice is breast milk jaundice?

A

Unconjugated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

How long can breast milk jaundice persist?

A

Up to 12 weeks from birth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Apart from breast milk and physiological what other causes of unconjugated infant jaundice are there?

A

-Sepsis -Haemolysis (excessive) -Abnormal conjugation

30
Q

Why might there be excessive haemolysis in a baby leading to jaundice?

A

-ABO incompatibility -Rhesus disease -Bruising/cephalhaematoma -Red cell membrane defects (e.g. spherocytosis) -Red cell enzyme defects (e.g. G6PD)

31
Q

What causes of abnormal conjugation are there?

A

-Gilbert’s disease (common, mild) -Crigler-Najjar syndrome (very rare but sever)

32
Q

What investigation would you do for sepsis causing jaundice?

A

-Urine culture -Blood culture -TORCH screen

33
Q

What investigation would you do for ABO incompatibility causing jaundice?

A

-Blood group -DCT

34
Q

What investigation would you do for Rhesus disease causing jaundice?

A

-Blood group -DCT

35
Q

What investigation would you do for bruising/cephalhaematoma causing jaundice?

A

Clinical examination

36
Q

What investigation would you do for red cell membrane defects causing jaundice?

A

Blood film

37
Q

What investigation would you do for red cell enzyme defects causing jaundice?

A

G6PD assay

38
Q

What investigation would you do for Gilbert’s disease causing jaundice?

A

Genotype/phenotype

39
Q

What investigation would you do for Crigler-Najjar syndorme causing jaundice?

A

Genotype/phenotype

40
Q

What is a possible complication of unconjugated jaundice?

A

Kernicterus

41
Q

Why does kernicterus occur?

A

-Unconjugated bilirubin is fat-soluble (water insoluble) so can cross blood-brain barrier -It is neurotoxic and deposits in brain (particularly the basal ganglia)

42
Q

What are the early signs of kernicterus?

A

-Encephalopathy -Poor feeding -Lethargy -Seizures

43
Q

What are the late signs of kernicterus?

A

-Severe choreoathetoid cerebral palsy -Learning difficulties -Sensorineural deafness

44
Q

How is unconjugated jaundice treated?

A

Phototherapy -Visible light (450nm wavelength) (not UV) converts bilirubin to water soluble isomer (photoisomerisation) -Threshold for phototherapy in infants guided by charts

45
Q

What is prolonged infant jaundice?

A

Jaundice persisting beyond 2 weeks of life or 3 weeks of life in preterms

46
Q

What are the conjugated causes of prolonged infant jaundice?

A

-Anatomical (biliary obstruction) -Neonatal hepatitis

47
Q

What are the unconjugated causes of prolonged infant jaundice?

A

-Hypothyroidism -Breast-milk jaundice

48
Q

What causes of biliary obstruction can lead to prolonged jaundice?

A

-Biliary atresia -Choledochal cyst -Alagille syndrome

49
Q

What is biliary atresia characterised by?

A

Conjugated jaundice with pale stools

50
Q

What is choledochal cyst characterised by?

A

Conjugated jaundice with pale stools

51
Q

What is Alagille syndrome characterised by?

A

-Intrahepatic cholestasis -Dysmorphism -Congenital cardiac disease

52
Q

What is biliary atresia?

A

Congenital fibro-inflammatory disease of the bile ducts leading to destruction of extra-hepatic bile ducts

53
Q

How does biliary atresia present?

A

-Prolonged conjugated jaundice -Pale stools and dark urine

54
Q

What can biliary atresia progress to?

A

Liver failure if not identified and treated (can occur within months of life)

55
Q

What is the most common indication for liver transplant in children?

A

Biliary atresia

56
Q

What is the treatment for biliary atresia?

A

Kasai portoenterostomy -Success rate diminishes rapidly with age -Best results if performed before 60 days (<9 weeks) -Small bowel divided and extrahepatic ducts removed. Liver bile ducts plugged directly into the small bowel

57
Q

What investigations are done for biliary atresia?

A

-Split bilirubin -Stool colour -Ultrasound -liver biopsy

58
Q

What investigations are done fro choledochal cyst?

A

-Split bilirubin -Stool colour -Ultrasound

59
Q

What investigations are done for Alagille syndrome?

A

-Dysmorphism -Genotype

60
Q

What causes of neonatal hepatitis are there?

A

-Alpha-1-antitrypsin deficiency -Galactosaemia -Tyrosinaemia -Urea cycle defects -Haemochromatosis -Glycogen storage disorders -Hypothyroidism -Viral hepatitis -Parenteral nutrition

61
Q

How is alpha-1 antitrypsin deficiency investigated?

A

Phenotype/level

62
Q

How is galactosaemia investigated?

A

GAL-1-PUT

63
Q

How is tyrosinaemia investigated?

A

Amino acid profile

64
Q

How are urea cycle defects investigated?

A

Ammonia levels

65
Q

How is haemochromotosis investigated?

A

-Iron studies -Liver biopsy

66
Q

How are glycogen storage disorders investigated?

A

Biopsy

67
Q

How is hypothyroidism investigated?

A

TFTs

68
Q

How is viral hepatitis investigated?

A

-Serology -PCR

69
Q

How is parenteral nutrition investigated?

A

History

70
Q

What should you always ask about with prolonged infant jaundice?

A

Stool colour

71
Q

What is the most important test fro prolonged infant jaundice?

A

Split bilirubin to determine if it is conjugated or unconjugated in nature

72
Q

What is the main diagnosis to exclude with conjugate prolonged jaundice?

A

Biliary atresia