Liver, Pancreas, Gall Bladder Flashcards
Why do gluconeogenesis?
To convert amino acids & lipids into glucose
Functions of Liver?
Gluconeogenesis, Detoxification, Storage, Production of Plasma Proteins, Production of Bile, Transfer of IgA
What is stored in the liver?
Glycogen, Triglycerides, and Vit A
What plasma proteins come from the liver?
Fibrinogen, Prothrombin, Albumin, Urea
Liver receives blood from ______.
Hepatic Artery and Portal Vein
Blood Leaves the liver through ______
Central Vein
What divides the liver into lobes?
Fibroconnective tissue capsule (Glisson’s capsule)
Another name for liver cells is…
hepatocytes
Cellular structures abundant in hepatocytes include…
rER, sER, lysosomes, peroxisomes, mitochondria, glycogen deposits, lipid droplets
Hepatocytes can be found in a ________ arrangement.
Hexagonal
What is unique about hepatocyte DNA?
Hepatocytes can be binucleate and have several times the normal DNA amount
Classical liver lobules are surrounded by…
Portal Canals
Please look at the different types of lobules pictures in the packet.
I’ll feel better if you’ve at least looked.
Phagocytic cells in the liver are called….
Kupffer Cells
Empty space in between the hepatocytes and the sinusoid epithelium?
Space of Disse
Describe a portal lobule.
Centered on portal area, defined by three adjacent central veins. Defines flow of bile into the bile duct.
Describe the hepatic acinus of Rappaport.
Oval region defined by two adjacent central veins. It defines a metabolic gradient from the periportal area to the drainage zone. (see pg. 2 of notes)
What does the space of disse do?
Exchanges material between the bloodstream and hepatocytes. Also storage.
Space of Disse is important in storage of…
Fat, Vit A
Bile flows in the _______ direction as blood.
Opposite
Name of intercellular spaces between hepatocytes
Bile Canaliculi
Describe the flow of bile out of the liver to the cystic duct.
Bile Canaliculi–> small bile ductules (canals of Hering) –> bile ducts –> hepatic ducts –> hepatic duct –> merge with cystic on gallbladder neck
What are 4 functions of bile?
- Excretion (Cholesterol, phospholipids, bile salts, conjugated bilirubin, and electrolytes.)
- Absorption of fat/fat soluble vitamins.
- IgA Transport
- -Excretion of Drugs/Heavy Metals
Describe the recycling of bile acids.
Reabsorbed by the ileum, in blood to the portal vein and liver sinusoids, hepatocytes extract from blood and resecrete into the canaliculi
