Liver Function Tests Flashcards
what two liver function tests signal hepatocellular injury?
AST and ALT
what three liver functions tests show cholestasis or obstruction?
alkaline phosphatase
GGT
bilirubin
what three liver function tests represent overall liver function?
bilirubin
albumin
PT/INR
which of AST or ALT is more specific?
ALT because the AST is found in other locations around the body
what are two other diseases that will increase AST?
cardiomyopathy
rhabdomyolysis
what do AST and ALT do in the liver?
help with gluconeogenesis
do AST/ALT levels go up or down with hepatocellular injury?
they go up
alkaline phosphate is found where in liver?
bile canaliculi
does alkaline phosphate go up or down with bile issues?
goes up
does glutamyl transferase (GGT) go up or down with bili issues?
goes up
what happens to albumin with liver damage? what about PT/INR?
albumin drops and PT goes up
what is the name of the enzyme that makes turns heme into biliverdin?
heme oxygenase
what is the name of the enzymes that makes bilverdin and links it with albumin?
biliverdin reductase
does unconjugated or conjugated bilirubin enter liver?
unconjugated
what is the name of the molecule in the liver that conjugates bilirubin?
UGT1A1