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GI Week 2 > IBD Pathophys > Flashcards

IBD Pathophys Flashcards

1
Q

name the three different types of colitis

A

active
chronic
chronic active

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2
Q

what three things do you have in active colitis?

A

neutrophils are present in crypts (cryptitis)
crypt abscess (neutros in crypt lumen)
ulceration

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3
Q

what must go wrong in chronic colitis?

A

altered crypt architecture

and increased lamina propria chronic inflammation

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4
Q

what is chronic active colitis?

A

chronic colitis with superimposed active colitis

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5
Q

in chronic colitis, there is more inflammation in the lamina propria, what cells are involved and where are they mainly located?

A

mostly plasma cells with some lymphocytes and eosinophils

they are more in the base of the crypts (normal is to be at apex)`

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6
Q

what is basal plasmacytosis associated with?

A

chronic colitis when you have a bunch of plasma cells in basal part of colonic crypts

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7
Q

which of acute versus chronic colitis has odd shaped crypts?

A

chronic colitis

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8
Q

is appendectomy protective for ulcerative colitis or Crohns?

A

ulcerative colitis

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9
Q

what are two diseases that fall under irritable bowel disease?

A

ulcerative colitis

crohns

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10
Q

how do IBDs develop? explain the three steps`

A

genetic predisposition
then
various triggers like bacterial/environmental
then
perfect storm of overly reactibe T cell (?) immune response in the gut

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11
Q

what cells do we suspect are mainly involved in the development of IBD?

A

T cells

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12
Q

where does UC only occur?

A

colon

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13
Q

is inflammation patchy or continuous in UC?

A

continuous `

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14
Q

what structure does UC always involve?

A

the rectum

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15
Q

where does inflammation occur in the tissue for UC?

A

only the mucosal surface

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16
Q

what are the main symptoms of UC?

A 
bad diarrhea, often bloody
urgency
progressive symptoms
sometimes abdominal pain
sometimes systemic things like fever and weight loss
17
Q

name the three types of UC and where they occur

A

proctitis- only rectum
left sided colitis- rectum and descending bowel
pan colitis- whole colon

18
Q

with UC what two things are kids at risk for?

A

malnutrition and growth failure

19
Q

what are three complications of UC?

A

bleeding
megacolon
colon cancer

20
Q

megacolon from UC can lead to what other issue?q

A

perforation

21
Q

which of UC or crohns leads to pseudopolyps? what are pseudopolyps?

A

UC

they are regenerated mucosa that appear like polyps but are not neoplastic

22
Q

where does Crohns occur?

A

any part of GI tract

23
Q

is crohnc inflammation patchy or continuous?

A

patchy

24
Q

what is the word that is used to describe the pattern of inflammation in crohns?

A

cobblestoning

25
Q

what parts of the gut tissue can crohns involve?

A

full thickness of the bowel wall

26
Q

what are the common symptoms of crohns disease?

A

diarrhea
abdominal pain
growth failure

27
Q

which of crohns or UC has abdominal pain commonly?

A

crohns

28
Q

which of Crohns or UC has systemic symptoms more commonly?

A

crohns has more fever/weight loss/fatigue than UC

29
Q

what are three complications that Crohns can cause?

A

fistulas
abscess
bowel obstructions (stricture)

30
Q

what are the three most common sites in GI for crohns to occur? in order of most common to least

A

ileocolic
small bowel only
colon alone

31
Q

name three rare locations for crohns to happen

A

gastroduodenal
proximal small bladder
esophagus

32
Q

what are five types of fistulas with crohns disease?

A 
enteroenteric
enterovesical
retroperitoneal
enterocutaneous
rectovaginal
perianal
33
Q

which of crohns or UC can have a perianal abscess?

A

Crohns

34
Q

which of UC or crohns has granulomas on histo?

A

Crohns does

35
Q

which of Crohns or UC has really large thickening of bowel walls?

A

Crohns because of transmural infiltration

36
Q

what is a joint issue you can have with IBD?

A

arthritis…often a sign of oncoming flare

37
Q

what is an oral issue you can have with IBD?

A

mouth ulcers

38
Q

what is a liver issue you can have with IBD?

A

PSC or inflamm of bile duct

39
Q

what are two skin lesions you can get with IBD?

A

erythema nodosum

pyoderma gangrenosum

GI Week 2 (12 decks)

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