IBD Pathophys

Question 1

name the three different types of colitis

Answer 1

active
chronic
chronic active

Question 2

what three things do you have in active colitis?

Answer 2

neutrophils are present in crypts (cryptitis)
crypt abscess (neutros in crypt lumen)
ulceration

Question 3

what must go wrong in chronic colitis?

Answer 3

altered crypt architecture

and increased lamina propria chronic inflammation

Question 4

what is chronic active colitis?

Answer 4

chronic colitis with superimposed active colitis

Question 5

in chronic colitis, there is more inflammation in the lamina propria, what cells are involved and where are they mainly located?

Answer 5

mostly plasma cells with some lymphocytes and eosinophils

they are more in the base of the crypts (normal is to be at apex)`

Question 6

what is basal plasmacytosis associated with?

Answer 6

chronic colitis when you have a bunch of plasma cells in basal part of colonic crypts

Question 7

which of acute versus chronic colitis has odd shaped crypts?

Answer 7

chronic colitis

Question 8

is appendectomy protective for ulcerative colitis or Crohns?

Answer 8

ulcerative colitis

Question 9

what are two diseases that fall under irritable bowel disease?

Answer 9

ulcerative colitis

crohns

Question 10

how do IBDs develop? explain the three steps`

Answer 10

genetic predisposition
then
various triggers like bacterial/environmental
then
perfect storm of overly reactibe T cell (?) immune response in the gut

Question 11

what cells do we suspect are mainly involved in the development of IBD?

Answer 11

T cells

Question 12

where does UC only occur?

Answer 12

colon

Question 13

is inflammation patchy or continuous in UC?

Answer 13

continuous `

Question 14

what structure does UC always involve?

Answer 14

the rectum

Question 15

where does inflammation occur in the tissue for UC?

Answer 15

only the mucosal surface

Question 16

what are the main symptoms of UC?

Answer 16

bad diarrhea, often bloody
urgency
progressive symptoms
sometimes abdominal pain
sometimes systemic things like fever and weight loss

Question 17

name the three types of UC and where they occur

Answer 17

proctitis- only rectum
left sided colitis- rectum and descending bowel
pan colitis- whole colon

Question 18

with UC what two things are kids at risk for?

Answer 18

malnutrition and growth failure

Question 19

what are three complications of UC?

Answer 19

bleeding
megacolon
colon cancer

Question 20

megacolon from UC can lead to what other issue?q

Answer 20

perforation

Question 21

which of UC or crohns leads to pseudopolyps? what are pseudopolyps?

Answer 21

UC

they are regenerated mucosa that appear like polyps but are not neoplastic

Question 22

where does Crohns occur?

Answer 22

any part of GI tract

Question 23

is crohnc inflammation patchy or continuous?

Answer 23

patchy

Question 24

what is the word that is used to describe the pattern of inflammation in crohns?

Answer 24

cobblestoning

Question 25

what parts of the gut tissue can crohns involve?

Answer 25

full thickness of the bowel wall

Question 26

what are the common symptoms of crohns disease?

Answer 26

diarrhea abdominal pain growth failure

Question 27

which of crohns or UC has abdominal pain commonly?

Answer 27

crohns

Question 28

which of Crohns or UC has systemic symptoms more commonly?

Answer 28

crohns has more fever/weight loss/fatigue than UC

Question 29

what are three complications that Crohns can cause?

Answer 29

fistulas abscess bowel obstructions (stricture)

Question 30

what are the three most common sites in GI for crohns to occur? in order of most common to least

Answer 30

ileocolic small bowel only colon alone

Question 31

name three rare locations for crohns to happen

Answer 31

gastroduodenal proximal small bladder esophagus

Question 32

what are five types of fistulas with crohns disease?

Answer 32

``` enteroenteric enterovesical retroperitoneal enterocutaneous rectovaginal perianal ```

Question 33

which of crohns or UC can have a perianal abscess?

Answer 33

Crohns

Question 34

which of UC or crohns has granulomas on histo?

Answer 34

Crohns does

Question 35

which of Crohns or UC has really large thickening of bowel walls?

Answer 35

Crohns because of transmural infiltration

Question 36

what is a joint issue you can have with IBD?

Answer 36

arthritis...often a sign of oncoming flare

Question 37

what is an oral issue you can have with IBD?

Answer 37

mouth ulcers

Question 38

what is a liver issue you can have with IBD?

Answer 38

PSC or inflamm of bile duct

Question 39

what are two skin lesions you can get with IBD?

Answer 39

erythema nodosum | pyoderma gangrenosum