liver Flashcards

bilirubin: explain the metabolism of bilirubin

1
Q

what is bilirubin predominantly derived from

A

Hb breakdown in spleen

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2
Q

what is bilirubin bound to when carried in the blood

A

albumin

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3
Q

what is unconjugated bilirubin conjugated into, where and by what

A

conjugated in liver by glucuronyl transferase into bilirubin glucoronide

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4
Q

what is unconjugated bilirubin conjugated into, where and by what

A

conjugated in liver by glucuronyl transferase into bilirubin glucoronide

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5
Q

where is bilirubin glucoronide secreted into and via what

A

into duodenum in bile via bile duct

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6
Q

where is bilirubin glucoronide secreted into and via what

A

into duodenum in bile via bile duct

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7
Q

what is bilirubin glucoronide degraded into in the gut by bacteria

A

urobilinogen, stercobilinogen - remain water soluble

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8
Q

fate of stercobilinogen

A

most oxidised to stercobilin (causes brown colour of faeces) in GIT, or reabsorbed and returned to liver via enterohepatic circulation

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9
Q

fate of stercobilinogen

A

most oxidised to stercobilin (causes brown colour of faeces) in GIT, or reabsorbed and returned to liver via enterohepatic circulation

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10
Q

enterohepatic circulation of bile salts

A

liver → excereted into biliary tree and GIT → absorbed in GIT → reabsorbed from portal circulation into liver from blood by active transport mechanism → very small amount lost so some primary bile salts produced in liver

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