liver Flashcards
bilirubin: explain the metabolism of bilirubin
what is bilirubin predominantly derived from
Hb breakdown in spleen
what is bilirubin bound to when carried in the blood
albumin
what is unconjugated bilirubin conjugated into, where and by what
conjugated in liver by glucuronyl transferase into bilirubin glucoronide
what is unconjugated bilirubin conjugated into, where and by what
conjugated in liver by glucuronyl transferase into bilirubin glucoronide
where is bilirubin glucoronide secreted into and via what
into duodenum in bile via bile duct
where is bilirubin glucoronide secreted into and via what
into duodenum in bile via bile duct
what is bilirubin glucoronide degraded into in the gut by bacteria
urobilinogen, stercobilinogen - remain water soluble
fate of stercobilinogen
most oxidised to stercobilin (causes brown colour of faeces) in GIT, or reabsorbed and returned to liver via enterohepatic circulation
fate of stercobilinogen
most oxidised to stercobilin (causes brown colour of faeces) in GIT, or reabsorbed and returned to liver via enterohepatic circulation
enterohepatic circulation of bile salts
liver → excereted into biliary tree and GIT → absorbed in GIT → reabsorbed from portal circulation into liver from blood by active transport mechanism → very small amount lost so some primary bile salts produced in liver