liver Flashcards

liver anatomy: describe the gross, structural and functional organisation of the liver

1
Q

what separates the left and right lobes of liver

A

falciform ligament

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2
Q

what are the two main perfusing vessels

A

hepatic artery from heart, hepatic portal vein from gut

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3
Q

separation of lobes

A

discrete segments with anatomical borders, independent blood supply, bile drainage

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4
Q

significance of lobe separation

A

able to have severe damage in one part without affecting other parts

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5
Q

subsection numbers

A

I-VIII, with IV split into upper (a) and lower (b) subsegments

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6
Q

drainage of liver

A

subsection drains into own vein, then into left, middle or right hepatic veins, before joining vena cava

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7
Q

what is a hepatic lobule

A

structural unit, roughly hexagonal, with each corner consisting of a portal triad linking with 3 adjacent lobules

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8
Q

what are the 3 conduit vessels/ducts in the portal triad

A

branch of hepatic portal vein, branch of hepatic artery, bile duct (from bile canaliculi)

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9
Q

in the lobule, which direction does blood flow

A

towards centre

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10
Q

in the lobule, which direction does bile flow

A

towards perimeter

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11
Q

what is at the centre of the liver lobule, and its function

A

central vein which collects blood draining from hepatic sinusoids

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12
Q

what is present in the lobule

A

rows of hepatocytes

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13
Q

two sides of hepatocytes

A

sinusois-facing, canaliculi-facing

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14
Q

what is a hepatic acinus

A

functional unit of liver tissue

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15
Q

what does a hepatic acinus consist of

A

2 adjacent 1/6 lobules that share 2 portal triads and extend as far into lobule as central veins

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16
Q

significance of acini arrangement for hepatocytes towards ouside of lobules

A

receive early exposure to blood components

17
Q

acini: zone 1

A

oxygen high, toxin risk high

18
Q

acini: zone 2

A

oxygen medium, toxin risk medium

19
Q

acini: zone 3

A

oxygen low, toxin risk low