LIPOPROTIEN A VS B

Question 1

What is Lipoprotein (a) associated with?

Answer 1

Increased risk of cardiovascular disease, particularly premature cardiovascular disease

Lipoprotein (a) is highly atherogenic.

Question 2

What type of particle is Lipoprotein (a)?

Answer 2

An LDL particle with a large protein, apo (a), attached covalently to apolipoprotein B

This structure allows it to incorporate into the arterial wall and contribute to atherosclerosis.

Question 3

In which condition may Lipoprotein (a) levels be modestly elevated?

Answer 3

Familial hyperlipidemia

Very high levels of Lipoprotein (a) are associated with a significant increase in atherosclerotic disease.

Question 4

What is the odds ratio for cardiovascular disease risk in persons with Lipoprotein (a) levels in the upper tertile?

Answer 4

1.7

Confidence interval is 95% Cl, 1.4-1.9.

Question 5

What does an elevated Apolipoprotein B suggest?

Answer 5

A diagnosis of familial hyperlipidemia and high risk of cardiovascular disease

However, this patient’s baseline LDL-cholesterol level ( 85) is not typical for familial hyperlipidemia.

Question 6

Fill in the blank: Lipoprotein (a) can contribute to _______.

Answer 6

Atherosclerosis

Question 7

WHEN YOU SUSPECT APO B

Answer 7

• This patient does not have diabetes or elevated triglycerides, which suggest apolipoprotein B and non-HDL cholesterol are not likely to be additionally informative beyond his LDL-cholesterol level