DPP4i MECHANISM Flashcards
What is GLP-1?
An incretin from the proglucagon gene in the small intestine’s L cells, secreted in response to nutrients; deficient in type 2 diabetes.
What are DPP-4 inhibitors?
Oral diabetes drugs that block the DPP-4 enzyme, which deactivates GLP-1.
What is the role of DPP-4 inhibitors in glucose regulation?
They could affect glucose regulation through various mechanisms.
What do incretin-based therapies include?
DPP-4 inhibitors and GLP-1 receptor agonists.
How do DPP-4 inhibitors affect GLP-1 levels?
They increase endogenous GLP-1.
What effects do DPP-4 inhibitors have on insulin and glucagon?
Stimulating glucose-dependent insulin secretion and lowering glucagon secretion.
What is one effect of DPP-4 inhibitors on hepatic glucose output?
Reducing hepatic glucose output.
What additional effects do GLP-1 receptor agonists have compared to DPP-4 inhibitors?
They slow gastric emptying and decrease food intake.
True or False: DPP-4 inhibitors affect insulin action or satiety.
False.
Fill in the blank: DPP-4 inhibitors do not affect _______.
insulin action or satiety.
