Lipoprotein Lipase Flashcards
1
Q
Function
A
hydrolyzes TAGs in chylomicrons and VLDL
cleaves the sn1 and sn3 ester bonds
phospholipase activity to open phospholipase shell
2
Q
Location
A
adipose tissue striated muscle lactating mammary gland heart -bound to heparin sulfate carbohydrate chains of glyxocalix at luminal surface
3
Q
Increased LPL activity
A
by insulin in adipose tissue
starvation in skeletal muscle and heart
prolactin in lactating mammary gland
4
Q
Hepatic lipase
A
instead of LDL in liver lipid hydrolase acts on IDL and HDL2 cleaves both TAGs and phospholipids plays a role in conversion of HDL2 back to HDL3
5
Q
LDL, HL, pancreatic lipase PL and endothelial lipase
A
Ser-His-Asp triad in catalytic site
LPL requires C2 apoprotein as cofactor
PL reguires colipase as cofactor
6
Q
Chylomicronemia syndrome
A
accumulation of chylomicrons in blood- high TAG conc.
eruptive xanthomas
lipemia retinalis
abdominal symptoms
7
Q
LPL deficiency
A
rare, autosomal recessive disorder
clearance of chylomicrons from blood diminished
elevated fasting plasma TAG level
risk of pancreatitis
