Lactic acidosis Flashcards
1
Q
Lactate
A
produced anaerobically
RBCs, kidney medulla, white skeletal muscle
lactate dehydrogenase
2
Q
Possible removal of excess lactate
A
- oxidation
aerobic
ATP;CO2;PDH
18 ATP produced - Gluconeogenesis
liver, kidney
3mol ATP produced - minor pathways
triacyglycerols, amino acids
3
Q
Effects leading to lactic acidosis
A
- Lactate overproduction
- Inhibition of PHD complex
- Inhibition of gluconeogenesis
- Dysregulated pyruvate-overproduction
- Liver insufficiency
4
Q
Lactate overproduction
A
intense muscle work respiratory obstruction insufficient circulation troubles in blood O2 supply troubles in O2 utilization in tissues
5
Q
Inhibition of PDH complex
A
thiamine deficiency
PDH enzyme deficiency
increased FA oxidation
enzyme deficiency in FA oxidation
6
Q
Inhibited gluconeogenesis
A
poisoning
enzyme defect
