Ketogenesis Flashcards

1
Q

Location

A

made in liver mitochondria

energy for extra hepatic tissue

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2
Q
  1. Acetyl CoA + Acety CoA -> Acetoacetyl-CoA
A
  • CoASH
  • condensation
  • reversible
  • enzyme: THIOLASE
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3
Q
  1. Acetoacetyl-CoA -> B-Hydroxy-B-methylglutaryl-CoA
A

Acetoacetyl-CoA + Acetyl CoA + H2O-> HMG-CoA + CoASH

  • condensation
  • enzyme: HMG-CoA SYNTHASE
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4
Q
  1. HMG-CoA -> Acetoacetate
A
  • acetyl CoA
  • cleavage
  • enzyme: HMG-CoA LYASE
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5
Q
  1. Acetoacetate -> Acetone
A
  • decarboxylation
  • spontaneous
  • enzyme: ACETOACETATE DECARBOXYLASE
  • infequently
  • toxic
  • breath it out
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6
Q
  1. Acetoacetate -> D-B-hydroxybutyrate
A
  • reduction
  • NADH->NAD+
  • reversible
  • enzyme: D-B-HYDROXYBUTYRATE DEHYDROGENASE
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