Ketogenesis Flashcards
1
Q
Location
A
made in liver mitochondria
energy for extra hepatic tissue
2
Q
- Acetyl CoA + Acety CoA -> Acetoacetyl-CoA
A
- CoASH
- condensation
- reversible
- enzyme: THIOLASE
3
Q
- Acetoacetyl-CoA -> B-Hydroxy-B-methylglutaryl-CoA
A
Acetoacetyl-CoA + Acetyl CoA + H2O-> HMG-CoA + CoASH
- condensation
- enzyme: HMG-CoA SYNTHASE
4
Q
- HMG-CoA -> Acetoacetate
A
- acetyl CoA
- cleavage
- enzyme: HMG-CoA LYASE
5
Q
- Acetoacetate -> Acetone
A
- decarboxylation
- spontaneous
- enzyme: ACETOACETATE DECARBOXYLASE
- infequently
- toxic
- breath it out
6
Q
- Acetoacetate -> D-B-hydroxybutyrate
A
- reduction
- NADH->NAD+
- reversible
- enzyme: D-B-HYDROXYBUTYRATE DEHYDROGENASE