Carbohydrate metabolism Flashcards

1
Q

GLUT 1/GLUT 3

A
  • high affinity, low capacity- Km= 1mM
  • expressed in all cells except hepatocytes and pancreatic beta cells
  • part of blood-brain barrier and blood-placenta barrier
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2
Q

GLUT 2

A
  • low affinity, high capacity- Km=12mM
  • expressed in hepatocytes and pancreatic beta cells
  • make glucose uptake proportional with blood glucose conc.
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3
Q

GLUT 4

A
  • intermediate affinity- Km=5mM
  • insulin-regulated
  • expressed in skeletal muscle and adipocytes
  • adjust consumption to availability
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4
Q

GLUT 5

A
  • expressed in intestinal epithelial cells and renal tubular epithelial cells
  • fructose absorption and reabsorption
  • works together with Na+/K+ ATPase and glucose-Na+ symport
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