Carbohydrate metabolism Flashcards
1
Q
GLUT 1/GLUT 3
A
- high affinity, low capacity- Km= 1mM
- expressed in all cells except hepatocytes and pancreatic beta cells
- part of blood-brain barrier and blood-placenta barrier
2
Q
GLUT 2
A
- low affinity, high capacity- Km=12mM
- expressed in hepatocytes and pancreatic beta cells
- make glucose uptake proportional with blood glucose conc.
3
Q
GLUT 4
A
- intermediate affinity- Km=5mM
- insulin-regulated
- expressed in skeletal muscle and adipocytes
- adjust consumption to availability
4
Q
GLUT 5
A
- expressed in intestinal epithelial cells and renal tubular epithelial cells
- fructose absorption and reabsorption
- works together with Na+/K+ ATPase and glucose-Na+ symport