lipid 3 Flashcards
Receptor Mediated Endocytosis
cholesterol homeostasis (maintained in cholesterol balance
Familial hypercholesterolemia –
genetic disease that results in the inability of cells to take up cholesterol by LDL, high cholesterol in the bloodstream
CLustering of LDL receptors when one receptor recognizes
APO B of LDL
receptor clustering signal
fatty coat= clathrin
clathrin
membrane nvaginate
endocytic vesicle made when
cinvagination occurs
formation of endosome
triggers separation of rceptor and LDL particle
tf at endsome receptor is degrades
F recycled back to membrane
at the lysosome
APO B–> AA
Chol–> chol and FA
in lysosome
What can you do with chol broken down from endosome
adrenal gland —> form steroid hormone liver cell–> make bile acid
tf after Chol is made in endsome it can go to membrane biogenesis and also be stored
T
ACAT
Chol–> CE(after endosome chol formation)
HMG COa reductase
turns off cholesterol formation
liver and adrenal gland
factories of cholesterol
other cells of body
down reg of Chol synthesis
removal of chol
liver make bile acid then to intestine feces (removed chol)
Reverse Cholesterol Transport
involving HDL
ABCA1 transport
binds APOA1 and transport Chol and Pl out of peripheal cell
Chol and PL taken out of perphery cell and agg with
APOA1
ABCA1 transport
active transporter
in peripheal blood stream
phospholipid bilayer(PL and chol)
Nascent HDL
phospholipid bilayer(PL and chol) with APO A wrapped on edges
cofactor APOA and
LCAT
Chol–> CE
LCAT
LCAT
make CE with phospholipid and APOA1
Chol and FA from PL
make CE
Ce
apolar and cant be in bilayer
Chol and FA from Pl
make CE thru LCAT
CE goes liver
thru HDL that binds to SRB1
selective uptake
Liver takes in Ce
leftover after slecetive uptake of CE
Pl and APO A1
CE in liver
metab to bile acid and removed from blood
