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Biochem block 3 > lipid 3 > Flashcards

lipid 3 Flashcards

1
Q

Receptor Mediated Endocytosis

A

cholesterol homeostasis (maintained in cholesterol balance

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2
Q

Familial hypercholesterolemia –

A

genetic disease that results in the inability of cells to take up cholesterol by LDL, high cholesterol in the bloodstream

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3
Q

CLustering of LDL receptors when one receptor recognizes

A

APO B of LDL

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4
Q

receptor clustering signal

A

fatty coat= clathrin

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5
Q

clathrin

A

membrane nvaginate

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6
Q

endocytic vesicle made when

A

cinvagination occurs

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7
Q

formation of endosome

A

triggers separation of rceptor and LDL particle

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8
Q

tf at endsome receptor is degrades

A

F recycled back to membrane

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9
Q

at the lysosome

A

APO B–> AA

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10
Q

Chol–> chol and FA

A

in lysosome

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11
Q

What can you do with chol broken down from endosome

A

adrenal gland —> form steroid hormone liver cell–> make bile acid

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12
Q

tf after Chol is made in endsome it can go to membrane biogenesis and also be stored

A

T

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13
Q

ACAT

A

Chol–> CE(after endosome chol formation)

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14
Q

HMG COa reductase

A

turns off cholesterol formation

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15
Q

liver and adrenal gland

A

factories of cholesterol

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16
Q

other cells of body

A

down reg of Chol synthesis

17
Q

removal of chol

A

liver make bile acid then to intestine feces (removed chol)

18
Q

Reverse Cholesterol Transport

A

involving HDL

19
Q

ABCA1 transport

A

binds APOA1 and transport Chol and Pl out of peripheal cell

20
Q

Chol and PL taken out of perphery cell and agg with

A

APOA1

21
Q

ABCA1 transport

A

active transporter

22
Q

in peripheal blood stream

A

phospholipid bilayer(PL and chol)

23
Q

Nascent HDL

A

phospholipid bilayer(PL and chol) with APO A wrapped on edges

24
Q

cofactor APOA and

A

LCAT

25
Q

Chol–> CE

A

LCAT

26
Q

LCAT

A

make CE with phospholipid and APOA1

27
Q

Chol and FA from PL

A

make CE

28
Q

Ce

A

apolar and cant be in bilayer

29
Q

Chol and FA from Pl

A

make CE thru LCAT

30
Q

CE goes liver

A

thru HDL that binds to SRB1

31
Q

selective uptake

A

Liver takes in Ce

32
Q

leftover after slecetive uptake of CE

A

Pl and APO A1

33
Q

CE in liver

A

metab to bile acid and removed from blood

Biochem block 3 (12 decks)

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