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Biochem block 3 > CT1 > Flashcards

CT1 Flashcards

1
Q

TF CT has only structural role

A

F its dynamic and Biologically interactive function

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2
Q

Connective tissue was critical to the evolution of ——– organisms.

A

Connective tissue was critical to the evolution of multicellular organisms.

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3
Q

❂ Extracellular matrix (ECM) is the material outside of the cells and —– and ——borders.

A

❂ Extracellular matrix (ECM) is the material outside of the cells and epithelial and endothelial borders.

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4
Q

CT

A

cells plus the ECM

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5
Q

TF The ECM is an extension of the cell and participates PassivELY in cell function.

A

The ECM is an extension of the cell and participates ACTIVELY in cell function.

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6
Q

CT

A

Stabilize the physical structure of tissues

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7
Q

protein PG GP

A

CT

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8
Q

major protein of CT

A

elastin

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9
Q

Allowed emergence of efficient circulatory and respiratory systems

A

elastin

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10
Q

order the following Translation Transcription (tropoelastin and microfibril components) Fiber formation Secretion

A

Transcription (tropoelastin and microfibril components) Translation Secretion Fiber formation

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11
Q

igf1 , tgf beta

A

ELN increased

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12
Q

TNFα (bFGF) HB-EGF

A

Decrease ELN transcription

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13
Q

The product of the ELN gene is

A

The product of the ELN gene is tropoelastin

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14
Q

Tropoelastin

A

Tropoelastin is secreted into the ECM.

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15
Q

Cross-linking renders the elastin fiber highly insoluble.—–

A

Cross-linking renders the elastin fiber highly insoluble.

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16
Q

crosslinking of Tropoelastin

A

elastin fiber

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17
Q

ECM;

A

tropelastin + microfibrils

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18
Q

tf tropoelastin nevr binds to microfibrils

A

F they bind

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19
Q

lysyl oxidase

A

mediates cross linking

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20
Q

tf elastin molecules can expand and contract

A

T

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21
Q

TF Treatment with NaOH at high temperature solubilizes virtually all proteins and the insoluble elastin.

A

Treatment with NaOH at high temperature solubilizes virtually all proteins, but not the insoluble elastin.

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22
Q

Tf In vitro, there are enzymes known as elastases that can cleave the elastin fiber.

A

In vivo, there are enzymes known as elastases that can cleave the elastin fiber.

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23
Q

cutis laxa

A

elastin mut–> skin laxity

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24
Q

narrow aorta , heart failure

A

Supravalvular aortic stenosis

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25
Q

rupture of aorta

A

Aortic aneurysm (ellastin problem)

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26
Q

lesions from plaque rupture leads to heart attack and stroke

A

Atherosclerosis (ellastin problem)

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27
Q

heart defect dental defect varying degrees of cognition issues

A

Williams syndrome

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28
Q

william syndrome

A

hypersociable and face morphology

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29
Q

chromosome 7 deletion and elastin deletion

A

william syndrome

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30
Q

after simulation of orthodontic force; Expression of tropoelastin in human periodontal ligament fibroblasts

A

increased significantly

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31
Q

Niccolò Paganini Bradford Cox

A

Marfan’s Syndrome (Fibrillin Mutations)

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32
Q

hypermobility and heart issus

A

Niccolò Paganini Bradford Cox

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33
Q

Cardiovascular ❂ Ocular

A

Marfans’ syndrome

34
Q

Skeletal ❂ Bone overgrowth ❂ Joint laxity

A

Marfan’s syndrome

35
Q

Periodontal disease

A

Marfan’s syndrome

36
Q

mutation fibrillin in Marfan’s disease

A

cant hold tgf beta

37
Q

matrix metaloprotein release

A

lead to tissue degradation –> CV problem and periodontitis

38
Q

Form a highly hydrated, gel-like ground substance

A

PG

39
Q

tf PG are homogenious

A

F

have other substances embedded in it like bfgf

40
Q

PG

A

carb rich

41
Q

polyanion and bind water

A

PG

42
Q

has low amt of protein in it (5%)

A

PG

43
Q

Osteoporosis and Osteoarthritis

A

PG ass disease

44
Q

hyper extensible skin and joints

fragile BV

A

ehlers danlos

45
Q

Ostero arthritis

A

lower bone mass(loss of PG components)

46
Q

deg joint disease

A

Osteoarthritis

47
Q

corneal disease

A

disfunction of PG

48
Q

tooth development •

dentin formation and mineralization •

adhesion and fusion of the palatal shelves

A

PG in oral cavity

49
Q

Proteoglycan-associated sugars

A

chondroitin sulfate and heparan sulfate

50
Q

(chondroitin sulfate and heparan sulfate

A

expressd in PDL in responce to orthodontic force

51
Q

periodontal regeneration.

A

Decorin (up-regulated)

Biglycan (down-regulated

types of PG

52
Q

Delivery of perlecan (heparan sulfate) may serve as a potential adjunct to stimulate — ——-

A

Delivery of perlecan (heparan sulfate) may serve as a potential adjunct to stimulate bone-regeneration.

53
Q

Delivery of perlecan (heparan sulfate) may trigger

A

tumorigenesis

54
Q

promoting cell adhesion,

and angiogenesis

A

Perlican

55
Q

proliferation, differentiation

A

perlican(PG)

56
Q

angiogenesis

A

PG

57
Q

Proteins + glycosaminoglycan

A

Proteins + glycosaminoglycans = proteoglycans

58
Q

tf Proteins + glycosaminoglycans are non covalently linked

A

F covalently linked

59
Q

glucosamine or galactosamine

A

conatined in GAG(at least 1)

60
Q

At least one of the sugars in the disaccharide of GAG is ——-

charged

A

At least one of the sugars in the disaccharide is negatively charged

61
Q

Negatively charged groups are either —– or —— groups

A

Negatively charged groups are either carboxylate or sulfate groups

62
Q

Disaccharide repeating units

A

GAGs

63
Q
A
64
Q

where on sugar is amine groups and acetyl groups added

A
65
Q

Hyaluronic acid is a —— of alternating units of glucuronic acid and N-acetylglucosamine.

A

Hyaluronic acid is a heteropolymer of alternating units of glucuronic acid and N-acetylglucosamine.

66
Q

Only GAG found free i.e. not covalently linked to a protein core.

A

Hyaluronic acid

67
Q

carboxylated in Hyaluronan GAG

A

glucoronic acid

68
Q

iduronic acid and N-acetylgalactosamine 4 sulfate

A
69
Q

carboxylate and sulffates

A

iduronic acid and N-acetylgalactosamine

dermatan sulfate GAG

70
Q

heparin sulfate

A

3 types of domains

sulfated domain

sulfated/acetylated domain

acetylated domain

71
Q

long or short

hydration varies

A

GAG

72
Q

Gag bind to core protein in PG through

A

tetrasaccharide

73
Q

o linked sugard

A

core protein to tetrasccharide

74
Q

PG

A

1 core many gags

75
Q

tetrasach. linkage allows

A

SEr to be covalently linked to xylose(of link tetra sacc)

76
Q

TF PG doesnt show variation with size

A

F 11KDa ro 220 KDa

77
Q

acan

A

encodes aggrecan

78
Q

middle of agrecan

A
79
Q

linker protein of aggrecan

A

links core protein to hyaluronic acid

80
Q

linker protein

A

non cov linkage

81
Q

GAGs to core protein

A

Covalent linkage

82
Q
A

Biochem block 3 (12 decks)

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