Limb Formation Flashcards
1
Q
Tetrapod
A
four limbed vertebrate
2
Q
Autopod
A
Carpals
3
Q
Stylopod
A
Humerus
4
Q
Zeugopod
A
Radius/Ulna
5
Q
When does limb formation occur
A
After most organ systems already developed
6
Q
Limb bud field
A
The area of the mesoderm that can form the limb bud
7
Q
Lateral plater mesoderm
A
Mesenchymal cells from the LPM undergo EMT to migrate into the limb bud and contribute to the growth
8
Q
Hox genes
A
Help specify limb field
9
Q
How limb bud formation is initiated
A
RA restricts FGF8 in the field and activates Tbx5
10
Q
How to detect RA in vivo
A
RAR-lacZ RA transgene
11
Q
Limb identity facors
A
In chicks and FGF soaked bead forms forelimb with tbx5 anteriorly
In mice, Hindlimb initiation is started by Islet1 and Pitx1 contributes to hindlimb character
