Kidney Organogenesis

Question 1

Tubulogenesis

Answer 1

Cell organization to form tube structures

Question 2

Nephron

Answer 2

The blood filtering unit of the kidney

Question 3

Collecting duct

Question 4

Glomerulus

Answer 4

Where blood capillaries release fluid and salts into the tubule

Question 5

Intermediate mesoderm

Answer 5

Establish kidney location
BMP4 helps contribute to mesoderm patterning
HOX11 helps specify A/P patterning

Question 6

Paraxial mesoderm

Answer 6

induces formation of the pronephros
Seen through PRX2 staining

Question 7

Pronephros

Answer 7

Transient, non functional in humans

Question 8

Mesonephros

Answer 8

“wolfian duct”
Nephric duct, elongates and gives rise to the ureteric bud that forms collecting ducts and ureters to carry urine to the bladder

Question 9

Metanephros

Answer 9

Permanent kidney structure

Question 10

Nephric duct

Answer 10

Gives rise to the ureteric bud

Question 11

Ureteric bud (epethilial)

Answer 11

Forms urinary collecting ducts and ureters as well as induces the development of nephrons
Ends of UB branches release WNT 9b and WNT 6 which causes MM to M-E transition

Question 12

Metanephric Mesenchyme

Answer 12

Makes all cell types for mature nephron
WNT 4 expression in MM causes renal vesicles which causes nephron formation
MM causes UB branching