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Pharmacology > Ligands > Flashcards

Ligands Flashcards

1
Q

Agonist

A

Has affinity and intrinsic activity
Mimic actions of endogenous compounds

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2
Q

Antagonists

A

Have affinity
No intrinsic activity
Block effect of agonist

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3
Q

Produces all of the effects of receptor
Maximal response

A

Full agonist

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4
Q

Full Agonist

A

Morphine
Isoproterenol

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5
Q

Produces some of the effects of the receptor; has a mixed agonist
and antagonist action

A

Partial Agonist

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6
Q

Full agonist + Partial Agonist

A

Partial Agonist becomes Antagonist

Ex. Morphine + Nalbuphine
Morphine is a full agonist to mu receptors while Nalbuphine is a partial agonist for same receptor, when taken together, result is reduction of analgesia

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7
Q

Partial Agonists

A

Nalbuphine
Tamoxifen
Buprenorphine
Varenecline

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8
Q

Partial Agonists

A

Nalbuphine
Tamoxifen
Buprenorphine
Varenicline

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9
Q

Ligand which produces an effect opposite to that of an agonist occupying the same receptor

A

Inverse Agonist

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10
Q

Inverse Agonist

A

Block constitutive activity
Ex. Beta-Carboline

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11
Q

Inhibit the actions of agonist

A

Antagonist

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12
Q

Produces opposite effects by binding to same or similar receptors

A

Pharmacologic or Receptor Antagonism

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13
Q

Act by interfering w/ binding of the endogenous ligand to the receptor as the agonist; Ionic Bond

A

Reversible, Competitive Antagonist

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14
Q

Atropine + Ach
Zafirlukast + Zileuton

A

Reversible, Competitive Antagonist

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15
Q

Acts by interacting w/ the non-ligand binding site of the receptor

A

Non-Competitive Antagonist

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16
Q

PPI + Hyperacidity

A

Non-Competitive Antagonist

17
Q

Allosteric Antagonist

A

Site other than the agonist binding site
Non-competitive Antagonist

18
Q

Produces opposite effects by binding to different receptors; 2 ligands acting on different receptors

A

Pharmacologic Antagonist / Receptor Antagonism

19
Q

Anaphylaxis & Antihistamines (Diphenhydramine)
Epinephrine & Beta-blockers

A

Pharmacologic Antagonist / Receptor Antagonism

20
Q

Does not act on receptors, direct interaction between agonist and antagonist

A

Chemical Antagonist

21
Q

Protamine + SO4, Antacid + Hyperacidity

A

Chemical Antagonist

by Neutralization or Chelation

Pharmacology (26 decks)

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