Androgens/Antiandrogens

Question 1

Testosterone

Answer 1

• Primary and secondary sex characteritics in males during pruberty
• Increase lean body mass and skeletal growth
• Increase production of erythropoietin in the kidneys

Question 2

Androgens

Answer 2

Testosterone
Methyltestosterone
Anabolic Steroids
* Oxandralone
* Fluoxymesterone
Danazol

Question 3

Treatment of hypogonadism & prevent osteoporosis in older men

Answer 3

Testosterone
Methyltestosterone

Can cause hepatic damage and liver failure

Question 4

Danazol

Answer 4

Weak androgenic activity
Treatment of endometriosis
Heavy uterine bleeding
Fibrocystic breast disease

Question 5

Anti-Androgens

Answer 5

Gonadotropin-Releasing Hormone Analogs

Androgen Receptor Antagonist
* Flutamide
* Bicalutamide
* Nilutamide

5a-Reductase Inhibitors
* Finasteride
* Dutasteride

Synthesis Inhibitor
* Ketoconazole

Question 6

Treatment of advance prostate cancer

Answer 6

Gonadotropin-releasing hormone analogues
* Leuprolide
* Abarelix
* Degarelix

Administered in continuous rather than pulsatile fashion

Question 7

Flutamide, Bicalutamide

Answer 7

Treatment of Prostate cancer
A/E: Impotence, Gynecomastia

Question 8

Treatment of BPH & Baldness

Answer 8

Finasteride
Dutasteride

Question 9

Adverse Efefcts of 5a-reductase inhibitors

finasteride, dutasteride

Answer 9

Erectile dysfuction
Decreased libido

CI: Pregnant, hypospadia