Dose-Response

Question 1

Shows the relationship between the degree of response w/ dose (Dose & Intensity of effect)

Answer 1

Graded Dose-Response Curve

Question 2

Graded response curve

Answer 2

Involves one patient only, assess safety, Continuous scale

Question 3

Parameters of Graded Dose-Response Curve

Answer 3

Potency
Efficacy/Ceiling Effect
Ceiling Dose
Slope

Question 4

Dose that produces 50% of the efficacy

Answer 4

Potency
↑Potency ↓Dose

Question 5

Maximum achievable response

Answer 5

Efficacy/Ceiling Effect
↑ Response ↑ Efficacy

Question 6

Smallest dose that produces the maximum achievable response; limit dose

Answer 6

Ceiling Dose

Question 7

Degree of change in response with a change in the dose

Answer 7

Slope

Question 8

Full Agonist + Non-Competitive Antagonist

Answer 8

↓ Potency ↓ Efficacy

Question 9

Cumulative number of Patients, relationship between Dose & frequency of Effect

Answer 9

Quantal Dose-Response Curve (All or None)

Question 10

Parameters in Quantal Dose-Response Curve

Answer 10

Median effective dose (ED50)
Median toxic dose (TD50)
Therapeutic Index (TD50/ED50)
Margin of Safety

Question 11

Dose that produces the beneficial response in 50% of the study population

Answer 11

Median Effective Dose (ED50)

Question 12

Dose that produces the toxic response in 50% of the study population

Answer 12

Median toxic dose (TD50)

Question 13

Relative measure of safety

Answer 13

Therapeutic Index (TD50/ED50)
(higher TI, safer drug)

Question 14

Measures drug’s clinical safety; drug is both safe and effective

Answer 14

Therapeutic Window

Question 15

Used in death responses in pre-clinical trials, i.e. in animals

Answer 15

Lethal Dose LD50