LG4.6 Pathology: Gout – Dr. Fischione Flashcards
1
Q
What are the general characteristics of Gout?
A
- Hyperuricemia
- Deposition of uric acid crystals
- Primarily joints, subcutaneous tissues, kidneys
2
Q
Who is most at risk for Gout?
A
- Men (95%)
- Alcohol use (Beer, liquor, wine)
3
Q
What are the cystals in Gout made of?
A
Monosodium Urate
4
Q
Symptoms of Acute Gout?
A
- Hyperemic, swollen, and warm
- Cannot walk
- Fever, leukocytosis, tachycardia, and general exhaustion
5
Q
Symptoms of Chronic Gout?
A
- Less inflammation
- More bone deformities (Mouth eaten bones)
- Tophi
6
Q
What and where is Tophi at?
A
- Often presents with subcutaneous deposits of uric acid
- Most often found on ears, the extensor sites of the arms, over the olecranon, and the patella
7
Q
What are the characteristic of Pseudogout?
A
- Old age with those over 85 y/o
- 2/3 have previous joint damage.
- IN THE KNEES
8
Q
What are the characteristics of the crystals of pseudo gout?
A
Short, stubby, and rhomboid
9
Q
What substance is in excess in Pseudogout?
A
- Inorganic pyrophosphate in the synovial fluid.
- Deposition of Calciu pyrophosphate in knees after trauma.
10
Q
In gout where do most crystals deposit?
A
In the kidneys
11
Q
What is podagra?
A
- 1st symptom of Gout
- Gout of the foot
- Causes seizure of the foot
