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NMSK A Test 2 > LG3.8 Pharmacology of Joint Infections – Dr. Wightkin > Flashcards

LG3.8 Pharmacology of Joint Infections – Dr. Wightkin Flashcards

1
Q

What does the stem name “cef” or “ceph”?

A

cephalosporin

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2
Q

What is the MOA of cephalosporin?

A

inhibits cell wall synthesis by transpeptide changes in

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3
Q

What is the MOA of Daptomycin?

A

Binds to bacterial membrane and cause depolarization of membrane potential. Results in inhibition of protein, DNA, and RNA synthesis.

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4
Q

What range of bacteria does Daptomycin treat?

A

Only Gram positive bacteria.

-Gas, pneumococci, MSSA, MRSA, Enterococci/VRE

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5
Q

What in the body interfere with the action of Daptomycin?

A

Daptomycin binds to lung surfactant and thus is ineffective agains pneumonia.

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6
Q

What are the adverse reactions of daptomycin?

A

decreased renal function, myoparht, Statins.

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7
Q

What is the MOA of Linezolid?

A

Binds to 23s ribosomal RNA of the 50S subunit

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8
Q

What are the ADME of linezolid?

A

Hepatic metabolism, IV and oral deliversimular serum levels; iv to oral switch de-escalation. Reversible bone marrow suppression (2 weeks of treatment)

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9
Q

What is serotonin syndrome?

A

Signs and symptoms include mental changes (confusion, hyperactivity, memory problems), muscle twitching, excessive swearing, shivering or shaking, diarrhea, trouble with coordination and or fever. Caused by Linezolid

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10
Q

What is the MOA of clindamycin?

A

Inhibits protein synthesis by binding to 50s ribosomal subunits

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11
Q

What is the spectrum of clindamycin?

A

Gram positive and Anaerobes

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12
Q

What drug has best activity against MSSA?

A

Cefazolin

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13
Q

What drug is used in treating meningitis, Lyme Dx, and gonorrhea?

A

Ceftriaxone

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14
Q

What drug is used in treating pseudomonas aeruginosa?

A

Ceftazidime, Cefepime

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15
Q

What drug is used to treat anaerobic bacteroides fragilis?

A

Cefoxitin

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16
Q

What drug is used to treat MRSA activity?

A

Ceftaroline

17
Q

What are side effects of ceftriaxone?

A

Billary sludge, biliary pseudolithiasis, and hyperbilirubinemia

18
Q

What are possible issue that may arise with ceftriaxone IV administration?

A

Calcium precipitates and reported deaths in 5 neonates

19
Q

What drug should linezolid not be given with that may cause serotonin syndrome?

A

SSRI (antidepressents)

20
Q

What new medication has the same MOA as Linezolid>

A

Tedizolid

21
Q

What is the spectrum of linezolid?

A
  • Gram positive

- Nonselective inhibitor of monoamine oxidase

NMSK A Test 2 (27 decks)

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