LG4.4 PODCAST: Pharmacology for Gout – Dr. Wightkin

Question 1

How is Gout managed?

Answer 1

1) Treating the acute attack
2) Providing prophylaxis to prevent acute flares.
3) Lowering excess stores of irate to prevent flares of gouty arthritis and to prevent tissue deposition of irate crystals

Question 2

What is the MOA of Colchicine?

Answer 2

• Inhibits or halts cell division by interfering with microtubules.
• Prevents polymerization
• Prevents activation of neutrophils

Question 3

What is the MOA of Allopurinol?

Answer 3

-Xanthine Oxidase inhibitors (indirectly)

Question 4

What is the MOA of Febuxostat?

Answer 4

Xathine Oxidase inhibitors (directly)

Question 5

What is the MOA of probenecid?

Answer 5

Blocks a renal tubular transporter of uric acid, increasing the amount excreted (Uricosuria)

Question 6

What is the MOA and use of Rasburicase?

Answer 6

• Directly converts uric acid to highly soluble allantoin

- Uricase for cancer patient because of tumor lysis

Question 7

What is the MOA of Pegloticase

Answer 7

• Uricase
• Chronic gout
• Refractory to conventional therapy

Question 8

What is tumor lysis syndrome?

Answer 8

-Chemotherapy increases uric acid levels.

Question 9

What is one of the allopurinol and Febuxostat?

Answer 9

Prolong 1/2 life of immunosuppressent such azathioprine prime and 6-mercaptopurine (immunosuppressants)