LG4.3 Arthritis II – Winfield Flashcards
What are general characteristics of reactive arthritis?
-Acute, polyarticular
What are the symptoms of reactive arthritis?
- Rash on hands, feet, penis.
- Urethritis, Iritis
What is the classic triad of reactive arthritis?
Arthritis, conjunctivitis, urethritis
What are the general symptoms of ankylosing spondylitis?
- persistent low back pain in teenager or early 20’s
- Spinal fusion with stooped posture and loss of spinal mobility
Define spondylitis?
A painful condition of the spine resulting from the degeneration of the intervertebral disks.
What are the main characteristics of ankylosing spondylitis?
- More males
- In lumbar spine, hips, pelvis, eye
- Seronegitive spondyloarthropathies
What are the main genetic predisposition of ankylosing spondylitis?
Class 1: HLA-B27
What are the general characteristics of Enteropathic arthritis?
- 20% of IBD develop a peripheral arthritis
- course of arthritis often fluctuates with the activity of the underlying bowel involvement.
- 10-20% spinal involvement
What are extra-articular manifestations of enteropathic arthritis?
Inflammatory eye disease and cutaneous lesions
What is the problem in psoriasis?
- The skin grows to quickly forming skin lesions.
- Nail discolorations and pitting
- can develop arthritis
What is the cause of psoriasis?
T-cell mediated disease with a genetic basis
Who gets psoriasis?
- Males=females
- Caucasians
What is the general characteristics of Psoriatic arthritis?
- Skin lesions and nail discoloration
- caused by psoriasis
What does it mean for a diseases to be Seronegitive spondyloarthropathies?
- No RF and ACPA values
- increased HLA-B27
What is Inflammatory bowel disease?
Diseases that cause chronic recurrent inflammation of the intestines
What are the causes of inflammatory bowel disease?
- Genetic family risk
- Caucasians have higher risk
- Jew have higher risk
- Ages 10-30 and 50-60
What are the symptoms of inflammatory bowel disease?
Abdominal cramps and pain, diarrhea, weight loss, and hematochezia
What are the clinical presentation of Rheumatoid Arthritis?
- Joint tenderness and swelling
- Morning joint stiffness for an hour or more
- Progressive joint destruction
What are extra-articular manifestations of Rheumatoid Arthritis?
-Scleritis, pericarditis, conduction defects, lung nodules, pulmonary fibrosis, gastritis, peptic ulcer disease 2nd to NSAIDS.
What is the cause of Rheumatoid Arthritis?
- Unknown
- Possible infectious agent
- Genetic factors
What are risk factors of Rheumatoid Arthritis?
- Female 3:1 male
- Smoking
- onset at any age, most common 40-50
What are lab test for Rheumatoid Arthritis?
- RF
- Anti-cyclic cirtullinated peptide(ACCP)
- Increased ESR
- Increased CRP
What are the non-pharmacologic treatments for Rheumatoid Arthritis?
- Heat
- Range of motion exercises
What are pharmacologic treatments for Rheumatoid Arthritis?
- NSAIDS
- Corticosteroids
- Disease Modifying Antirheumatic Drugs (DMARD)
- Oral Hydroxychloroquine, Sulfasalazine, and Methotrexate
What are the clinical presentation of erosive inflammatory osteoarthritis?
- Typical OA has enlargement of bones over the distal and proximal finger joints.
- Swelling of the soft tissue in the proximal and distal interphalangeal joints.
What are common labs for erosive inflammatory osteoarthritis?
- RF/ACCP are negative
- ESR and CRP increased
What are the treatments of erosive inflammatory osteoarthritis?
- ROM exercises
- PRN pain meds and no steroidal anti-inflammatory drugs for symptom relief
What are main lab values for septic arthritis?
-Lab: Synovial WBC >100,000 PMNs are 90% or above
What are main causes of septic arthritis?
- Mycrobacterium SPP
- Fungal infections
- Viral infections
