LFTs in chronic disease

Question 1

what are the components of LFT?

Answer 1

ALbumin, bilirubin
Enzymes: ALP, GGT, AST, ALT

Question 2

which conditions is albumin decreased in ?

Answer 2

malnutrition secondary to crohns, UC, Coeliac
kidney disease
liver disease

Question 3

when is albumin increased

Answer 3

severe infection, CID, Hepatitis

Question 4

what are the types of bilirubin assessed?

Answer 4

unconjugated and conjugated

Question 5

what does increased unconjugated bilirubin indicate?

Answer 5

Gilberts syndrome or haemolytic anaemia

Question 6

what does increased conjugated bilirubin indicate

Answer 6

liver or bile duct obstruction

Question 7

what causes the enzymes to generally increase?

Answer 7

chronic alcohol excess, obesity, drug use and smoking

Question 8

what does increased ALP indicate

Answer 8

bile duct obstruction
-obstructive liver disease
increased osteoblastic activity
- pagets
- osteomalacia
- Vit D def

Question 9

increased GGT indicates?

Answer 9

liver disease from drugs/alcohol

Question 10

increased AST, ALT indicates

Answer 10

drug and/or alcohol use, toxins, rural diseases

Question 11

increased GGT and ALP indicates

Answer 11

Biliary problems

Question 12

increased AST and ALT indicates

Answer 12

hepatic problems

Question 13

if GGT and ALP are higher than AST and ALT what is indicated?

Answer 13

obstructive jaundice