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Histology > Leukocytes > Flashcards

Leukocytes Flashcards

1
Q

mobile cells that leave circulation; WBCs stick to endothelial cell surface and squeeze between endothelial cells of capillaries & venules via pseudopodia; function as active part of immune system in tissues

A

leukocytes

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2
Q

any cell product that influences another cell, like pheromone

A

cytokines

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3
Q

acid dye that stains bases bright pink

A

eosinophilic dye

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4
Q

basic dye that stains acids deep blue/purple

A

basophilic dye (azurophilic)

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5
Q

neutrophils, basophils, and eosinophils that all have single, multi-lobed nucleus & prominent cytoplasmic granules (primary and secondary)

A

granulocytes

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6
Q

multi-lobed nucleus (3-5); short-lived; few mitochondria; primary granules contain unique antimicrobial myeloperoxidase

A

neutrophils

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7
Q

bacterial killing by generating hydrogen peroxide and hypocholorous acid

A

respiratory burst

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8
Q

immature neutrophils that cause a left shift similar to anemia

A

stab cells

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9
Q

inactive X chromosome in females

A

Barr body

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10
Q

mast cells in tissue; specific granules contain hydrolytic enzymes, heparin sulfate, chondroitin sulfate, histamine, leukotrienes; used in type 1 hypersensitivity reactions

A

basophils

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11
Q

remain in circulation 3-6 hours before entering tissue; lifespan 8-12 days; has IgE surface receptors; contains histaminase; important in hypersensitivity rxns; have antiparasitic function especially against flukes; parasites and affinity for Antigen-antibody complexes

A

eosinophils

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12
Q

monocytes and lymphocytes; have single, unlobed nucleus and lack secondary granules but have primary (azurophilic) granules

A

agranulocytes

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13
Q

abundant, gray-blue/lavender cytoplasm; large indented (kidney bean shaped) nucleus; present in bloodstream 2-3 days then extravasate, enter tissue then become macrophages; lifespan is several months

A

monocytes

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14
Q

fixed tissue macrophages in liver

A

kupfer cells

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15
Q

fixed tissue macrophages in CNS

A

microglial cells

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16
Q

fixed tissue macrophages in skin

A

Langerhans cells

17
Q

fixed tissue macrophages in lung

A

dust cells

18
Q

fixed tissue macrophages in bone

A

osteoclasts

19
Q

antigen stimulates ___ to form; macrophages fuse to form it

A

epithelioid giant cell

20
Q

WBC active in subacute to chronic infections; have lifespan of days to years; round, densely staining nucleus surrounded by thin rim of cytoplasm; 2 types: t and b cells

A

lymphocytes

21
Q

function in humorally mediated immune response and produce antibodies; formed and become immunocompetent in bone marrow; after encountering antigens, undergo multiple divisions to produce clones of antibody producing plasma cells

A

B cells

22
Q

formed in bone marrow but become immunocompetent in the thymus; have receptors (paratopes) that recognize antigens (epitopes); responsible for cell-mediated immunity and have long lifespan; 3 types

A

T cells

23
Q

primary effectors in cell-mediated immunity tend to be large that recognize cells with foreign surface antigens or receptors and kill them by punching holes in membrane

A

cytotoxic t cells

24
Q

detect invaders and sound chemical alarm; recognize antigens usually presented by macrophages or b cells then secrete cytokines

A

heler t cells

25
Q

suppress activity of b cells, dampen immune response, especially to self moleuces

A

suppressor cells

26
Q

lymphocytes which posses Fc receptors but lack specific cell surface markers of either b or t cells; include natural killer cells; responsible for nonspecific cytotoxicity against virus-infected and tumor cells

A

null cell

27
Q

most abundant to least abundant leukocytes

A

neutrophils, lymphocytes, monocytes, eosinophils, basophils

28
Q

Shows total number of WBCs

A

CBC (complete blood count)

29
Q

Shows relative percentages of WBCs

A

Differential cell count

30
Q

Increase in neutrophils shows ________

A

Acute, bacterial issue

31
Q

Increase in lymphocytes and monocytes shows _________

A

Subacute viral issue

32
Q

Increase in eosinophils shows ________

A

Allergies and parasites

33
Q

Increase in WBCs shows ______

A

Infection/tumor

34
Q

Decrease in WBCs shows ________

A

Immune suppression/tumor

35
Q

Neutropenia shows ______

A

Acute viral infection or severe sepsis

36
Q

Decrease in platelets shows ______

A

Thrombocytopenia

Histology (10 decks)

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