Cytoskeleton and Cell Division Flashcards
provide structural support for plasma membrane & organelles, intracellular movement/transport of substances, cell locomotion, muscle contraction
cytoskeleton
distributed in 3D network throughout cytoplasm; important in maintaining cell shape, facilitate shape changes during movement
microfilaments
thin microfilament made of protofilaments that twist together
actin
small globular protein monomer that polymerizes to form protofilaments
g-actin
polymer form of G-actin
protofilaments
2 protofilaments that twist together to form double helix that combine to form larger actin filaments
F-actin
support meshwork formed by actin and filamin that prevents cell from deformation
cell cortex (terminal web)
thick microfilament classified as a motor protein that are long and rod shaped with globular head that form thick, ropy cables and form cross bridges between adjacent filaments
myosin
size between microfilaments and microtubules; form large filaments that bind w intracellular structures useful in immunhistochemistry and tumor ID
intermediate filaments
intermediate filament characteristic of all epithelial cells; forms tonofibrils in epidermis of skin
cyto(keratin)
intermediate filaments found in mesodermal cells of messenchymal origin (includes endothelial cells, muscle, & neuroectodermal cells)
vimentin
intermediate filaments unique to muscle cells; mesodermal origin
desmin
intermediate filaments present in nerve cells
neurofilament proteins
intermediate filaments found in glial (support) cells of nervous system (astrocytes)
GFAP- glial fibrillary acidic protein)
intermediate filament that forms layer on inside of nuclear membrane
lamin
larger, composed of 2 globular protein subunits arranged in a coiled, spirall pattern that polymerize to form hollow tubes that readily assemble and disassemble
microtubule
9 pairs of microtubules (peripheral doublets) containing dyenin arms arranged in circle w central doublet structrue
axoneme
region of the cell known as the “cell center” near nucleus and function in cell division
centrosome
located in centrosome that consists of 9 triplets of microtubules arranged in a cylinder and acts as a nucleation center for microtubules
centriole
2 components that make up microtubules
alpha and beta tubulin
motor proteins that attach microtubules to organelles allowing movement in cytoplasm
dyenin and kinesin
growth and replication of cell
mitosis