Leukemias Flashcards
Type I Blasts
Myeloblasts/unclassifiable cells, no granules
Type II Blasts
<20 granules, N:C lower
Type III Blasts
> 20 granules
Nonerythroid nucleated cells (NEC)
Blasts
M0 AML
min dif, <3% SBB+, heterogeneous, no auer rods, TdT+
M1 AML
myelo, no maturation (15-20%)
M2 AML
myelo, mature (25-30%), t(8;21)(q22;q22)(AML1/ETO)
M3 APL
Young patients, ATRA, DIC, Promyelocytic, hypergranular (10-15%), t(15;17)(q22;q12)(PML/RARa)
M4 AMML, NSE, CAE
Myelomonocytic (20-30%), gums,
M4eo AMML
inv(16)(p13;q22) or t(16;16)(p13;22)(CBFB/MYH11)
M5a AMol, NSE+, MPO/SBB=
monoblastic, no maturation, 11q23 (MLL), gums
M5b AMol
monoblastic, matureM
M6 AEL, PAS+
erythroleukemia
M7 AMkL, CD41, 61, 42
megakaryoblastic
acute panmyelosis with myelofibrosis
AMkL w IMF