Lesson7&8 Flashcards
Modern genetics began with Gregor Mendel in
1865
models work was largely ignored until
1900
Nothing in biology makes sense except in the light of evolution
Theodosius Dobzhansky(1973)
Dominance
Heterozygote phenotype resembles only one of the homozygotes
Incomplete dominance
Heterozygote phenotype is intermediate between the homozygotes
Codominance
heterozygote phenotype is a mix between the two extreme homozygotes
Genotype
Set of alley that an individual has
population
all individuals of species living in a given place- can potentially interbreed.
Population genetics
Addresses origin, maintenance, structure and evolutionary change of genetic variation and allele frequencies in populations
features of hardy-weinberg Equilibrium(HWE)
- Assumptions
1) Infinite populatioon size
2) no gene flow
3) no mutations
4) random mating
5) no selection
Important features of Hardy- Weinberg Equilibrium(HWE)
- Implications
- Ideal population at HWE will not evolve; Allele frequencies in offspring population will be identical to allele frequencies in their parent population
- Population will evolve; allele frequencies will change from one generation to the next
- Assumptions of HWE are unrealistic
- Nearly all populations evolve
Important features of HWE
- summary
- Allele frequencies p and q correspond to different genotype frequencies in a natural population
- P and Q cannot predict frequencies in a given natural population
- ## given p and q, the HWE equation predicts genotype frequencies in a theoretical/ ideal population
Frameshifts and substitutions
- Simple changes at the genetic level can cause major changes in phenotypes and increase phenotypic variation
Mutation rate
- Rate of change in DNA sequence due to copying errors, external factors(UV radiation, X-rays) expressed as
number of mutations per nucleotide per generation