Lesson 11 - Exam 2 Flashcards
Pain =
Dolar.
Heat =
Calor.
Redness =
Rubor.
Swelling =
Tumor.
Vasodilation due to release of vasoactive and chemotactic factors will present as -
- Dolar (pain)
- Calor (heat)
- Rubor (Redness)
Increased permeability due to release of vasoactive and chemotactic factors will present as -
Tumor (swelling)
Neutrophil emigration deu to release of vasoactive and chemotactic factors will present as -
Tumor (Swelling)
Release of vasoactive and chemotactic factors will directly result as -
Dolar (pain)
________ ________ will cause release of chemotactic and vasoactive factors.
Tissue damage.
True or false: Inflammation is a result of cell injury, that will have specific responses depending on the cause of injury.
FALSE: Inflammation is a result of cell injury, that will have a non-specific response regardless of causation.
3 healing types:
- Scar tissue - From fibrosis.
- Regeneration - Replacement with same type of tissue cells, following irreversible damage.
- Resolution - Damaged cells recover, following reversible damage.
The following are all potential causes for what condition?
1. extension of acute inflammation.
2. Prolonged healing of acute inflammation.
3. Persistence of a causative agent.
Chronic inflammation.
Histamine is a a chemical mediator in inflammatory response: Name its Source and action -
Source:
Mast cell granule.
Action:
imediate vasodialation and increased capillary permeability to form exudate.
Chemotactic factors are chemical mediators in inflammatory response - Name its source and action:
Source: Mast cell granules.
Action: Attract neutrophils to a site of inflammation.
Platelet-activating factor (PAF) is a chemical mediator in the inflammatory response - name its source and action:
Source: Cell membrane of platelets.
Action: Platelet aggregation.
Cytokines (interleukins and lymphokines) are mediators in the inflammatory response - name its source and action:
Source: T-Lymphocytes and macrophages.
Action: increased plasma proteins, Induces fever, chemotaxis, and leukocytosis.
Neutrophil specific granule contents:
- phospholipase A2. **
- Myeloperoxidase.
- Cationic proteins.
- Acid hydrolases.
- Elastase. **
- Cathepsins
Neutrophil azurophilic granule contents:
- Phospholipase A2.
- Lysozyme.
- Alkaaline phosphatase.
- Type IC collagenase.
- Lactoferrin.
- Vitamin B-12 binding proteins
Neutrophil tertiary granule contents:
- Metalloproteinases
Eosinophil specific granule contents:
Crystalloid contents:
1. Major basic protein.
2. eosinophil cationic protein.
3. eosinophil peroxidase.
4. Eosinophil-derived neurotoxin.
5. Histaminase.
6. collagenase.
Eosinophil azurophilic granule contents:
Acid hydrolases, collagenases, other eisonphil-specific hydrolases.
Basophil specific granule contents:
Pre-formed mediators of the inflammatory response, including histamine, heparin sulfate, and chondroitin.
Cause synthesis of other mediators upon stimulation.
Basophil azurophilic granule contents:
Acid hydrolases.
________________ are white blood cells that are found inside the blood vessels, that act on cells outside of the blood vessel.
Inflammatory cells.
Inflammatory cell names - In the blood vessel vs in the target tissue:
Basophil (blood) ———> Mast cell (tissue)
Monocyte (blood) ———-> Macrophage (tissue)
Lymphocytes (blood) ———–> Plasma cells (tissue)
How do we name white blood cells?
- Based on appearance in blood smears stained with Wright’s stain.
- Named based on shape, size, prescence of granules, and color of granules.
True or false: Basophils and monocytes have no major granules.
False - Monocytes and lymphocytes have no major granules, while basophils have significant granules.
Under high magnification in monocytes and lymphocytes, we can see small azurophilic granules, what are these?
These are lysosomes, called non-specific granules.
________________ Inflammatory chemical mediators, will circulate the blood in their inactive form and will need to be activated at the site of inflammation.
Plasma derives inflammatory chemical mediators.