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Pharmacology > Leprosy > Flashcards

Leprosy Flashcards

1
Q

What is the primary causative agent of leprosy?

A

Mycobacterium leprae

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2
Q

True or False: Leprosy is primarily spread through respiratory droplets.

A

True

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3
Q

Which class of antibiotics is primarily used to treat leprosy?

A

Multidrug therapy (MDT) including rifampicin, dapsone, and clofazimine

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4
Q

What is the mechanism of action of rifampicin?

A

Inhibition of bacterial RNA synthesis

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5
Q

Fill in the blank: Dapsone is a _______ antibiotic.

A

sulfonamide

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6
Q

What is the role of clofazimine in leprosy treatment?

A

It acts as an antimicrobial and anti-inflammatory agent.

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7
Q

True or False: Leprosy can be completely cured with appropriate treatment.

A

True

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8
Q

What is the duration of treatment for leprosy with multidrug therapy?

A

6 months to 2 years, depending on the form of leprosy

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9
Q

Which drug is known to cause a reddish-brown discoloration of the skin?

A

Clofazimine

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10
Q

What adverse effect is associated with dapsone?

A

Hemolytic anemia

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11
Q

What is the standard treatment regimen for multibacillary leprosy?

A

Rifampicin, dapsone, and clofazimine for 12 months

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12
Q

True or False: Leprosy is a highly contagious disease.

A

False

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13
Q

What is the primary goal of leprosy treatment?

A

To kill the Mycobacterium leprae and prevent disability

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14
Q

Fill in the blank: The World Health Organization recommends _______ therapy for leprosy.

A

multidrug

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15
Q

What type of leprosy is characterized by a low bacterial load?

A

Tuberculoid leprosy

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16
Q

What is the primary method of diagnosing leprosy?

A

Clinical examination and skin smear or biopsy

17
Q

Which drug is contraindicated in patients with G6PD deficiency?

A

Dapsone

18
Q

What is the significance of the lepromin test?

A

It helps to determine the immune response to Mycobacterium leprae.

19
Q

True or False: Clofazimine is effective against other mycobacterial infections.

A

True

20
Q

What is the main side effect of rifampicin?

A

Hepatotoxicity

21
Q

What is the recommended treatment for a leprosy patient with a severe reaction?

A

Corticosteroids

22
Q

Fill in the blank: Leprosy primarily affects the _______ and _______ system.

A

skin, peripheral nervous

23
Q

What is the consequence of untreated leprosy?

A

Disability and deformities

24
Q

Which population is most at risk for developing leprosy?

A

Those with close, prolonged contact with infected individuals

25
Q

What is the purpose of contact tracing in leprosy management?

A

To identify and treat individuals who may have been exposed to the disease.

26
Q

True or False: Leprosy is a disease of the past and no longer occurs.

A

False

27
Q

What is the role of the skin smear test in leprosy diagnosis?

A

To detect the presence of Mycobacterium leprae.

Pharmacology (18 decks)

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