Antifungals Flashcards
What is the primary purpose of antifungal drugs?
To treat fungal infections.
True or False: Antifungal drugs are effective against bacterial infections.
False
Name one common type of antifungal drug.
Azoles
Fill in the blank: The mechanism of action for polyene antifungals involves binding to __________.
ergosterol
What is the mechanism of action of azole antifungals?
Inhibition of ergosterol synthesis.
Which antifungal class does Amphotericin B belong to?
Polyene
True or False: Echinocandins are effective against Candida species.
True
What is a common side effect of Amphotericin B?
Nephrotoxicity
Which antifungal drug is often used as a first-line treatment for cryptococcal meningitis?
Fluconazole
What is the primary target of echinocandin antifungals?
Fungal cell wall synthesis.
True or False: Nystatin can be used systemically.
False
What is the main condition treated with terbinafine?
Onychomycosis (nail fungus)
Which antifungal drug class is known for causing liver toxicity?
Azoles
Fill in the blank: __________ are antifungal agents that inhibit the synthesis of β-(1,3)-D-glucan.
Echinocandins
What is the systemic antifungal drug typically used for treating invasive aspergillosis?
Voriconazole
Which antifungal is used topically for treating athlete’s foot?
Clotrimazole
True or False: All antifungal drugs can be used interchangeably.
False
What is an important consideration when prescribing antifungal therapy?
Potential drug interactions.
Which antifungal drug is a prodrug that is converted to 5-fluorouracil?
Flucytosine
Fill in the blank: __________ is a broad-spectrum antifungal that can be used to treat fungal infections in neutropenic patients.
Posaconazole
What is the route of administration for most echinocandins?
Intravenous
Which antifungal drug is primarily used for treating mucormycosis?
Amphotericin B
True or False: Voriconazole has good activity against Candida species.
True
What is the mechanism of action of griseofulvin?
Inhibition of fungal mitosis.
Fill in the blank: The __________ is the fungal cell membrane component that is targeted by polyene antifungals.
ergosterol
Which antifungal drug is indicated for vaginal candidiasis?
Miconazole
What class of antifungal agents does caspofungin belong to?
Echinocandins
True or False: Antifungal resistance is a growing concern in clinical practice.
True
What is the primary use of ketoconazole?
Topical treatment of fungal infections.
Fill in the blank: __________ are the mainstay of treatment for superficial fungal infections.
Topical antifungals
