Antifungals Flashcards

1
Q

What is the primary purpose of antifungal drugs?

A

To treat fungal infections.

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2
Q

True or False: Antifungal drugs are effective against bacterial infections.

A

False

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3
Q

Name one common type of antifungal drug.

A

Azoles

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4
Q

Fill in the blank: The mechanism of action for polyene antifungals involves binding to __________.

A

ergosterol

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5
Q

What is the mechanism of action of azole antifungals?

A

Inhibition of ergosterol synthesis.

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6
Q

Which antifungal class does Amphotericin B belong to?

A

Polyene

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7
Q

True or False: Echinocandins are effective against Candida species.

A

True

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8
Q

What is a common side effect of Amphotericin B?

A

Nephrotoxicity

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9
Q

Which antifungal drug is often used as a first-line treatment for cryptococcal meningitis?

A

Fluconazole

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10
Q

What is the primary target of echinocandin antifungals?

A

Fungal cell wall synthesis.

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11
Q

True or False: Nystatin can be used systemically.

A

False

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12
Q

What is the main condition treated with terbinafine?

A

Onychomycosis (nail fungus)

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13
Q

Which antifungal drug class is known for causing liver toxicity?

A

Azoles

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14
Q

Fill in the blank: __________ are antifungal agents that inhibit the synthesis of β-(1,3)-D-glucan.

A

Echinocandins

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15
Q

What is the systemic antifungal drug typically used for treating invasive aspergillosis?

A

Voriconazole

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16
Q

Which antifungal is used topically for treating athlete’s foot?

A

Clotrimazole

17
Q

True or False: All antifungal drugs can be used interchangeably.

A

False

18
Q

What is an important consideration when prescribing antifungal therapy?

A

Potential drug interactions.

19
Q

Which antifungal drug is a prodrug that is converted to 5-fluorouracil?

A

Flucytosine

20
Q

Fill in the blank: __________ is a broad-spectrum antifungal that can be used to treat fungal infections in neutropenic patients.

A

Posaconazole

21
Q

What is the route of administration for most echinocandins?

A

Intravenous

22
Q

Which antifungal drug is primarily used for treating mucormycosis?

A

Amphotericin B

23
Q

True or False: Voriconazole has good activity against Candida species.

A

True

24
Q

What is the mechanism of action of griseofulvin?

A

Inhibition of fungal mitosis.

25
Q

Fill in the blank: The __________ is the fungal cell membrane component that is targeted by polyene antifungals.

A

ergosterol

26
Q

Which antifungal drug is indicated for vaginal candidiasis?

A

Miconazole

27
Q

What class of antifungal agents does caspofungin belong to?

A

Echinocandins

28
Q

True or False: Antifungal resistance is a growing concern in clinical practice.

A

True

29
Q

What is the primary use of ketoconazole?

A

Topical treatment of fungal infections.

30
Q

Fill in the blank: __________ are the mainstay of treatment for superficial fungal infections.

A

Topical antifungals