leishmanias Flashcards
agents of cutaneous leishamniasi
old word: tropica + major
new world: mexicana l braziliensis
what type of parasite is leishmania
protozoa
geographical preliclition of cutaneous leishmania
old world- europe, africa, asia
new world- south america
infective form
metacyclic promastigotes injected from bite of sandfly
can both sexes transmit the disease
just female needs blood to lay eggs
what kind of disease is cutaneous leishmaniasis
a zoonose
what kind of disease is visceral L
ZOOINOSE
typical characteristics of leishmania chancre
painless, non healing, grows over time and has an indurated border
types of old world chancres just list
- urban anthroponotic type
- rural zoonotic type
- localised cutaneous type
urban anthroponotic type+ what agent causes it
usually single, less inflammation and dry and less severe in comparison to wet type caused by tropica
zoonotic chancre type + agent
multiple, most more inflammation and more severe in comparison to dry type caused by major
diffuse cutaneous leishmaniasis
lesions do not ulcerate
linked to the competence of the immune system
more severe in comparison to basic types as resistant to treatment
diagnosis of cutaneous
skin scrapings + from border of the ulcer!!
method: impression (touch preparations) staining with giemsa- see amastigotes in marcophages
pcr
vector
sandfly
what form of the parasite will you find in humans
amastigote
which is more severe visceral or cutaneous
visceral as its system
chicleros ulcer caused by
l. mexicana
which is more severe old world or new world
NEW WORLD
culture of leishmania
NNN medium 24 degrees for 7 days
l. brazielens causes
espundia or mucocutaneous leishmaniasis
topical treatment of cutanoues
intralesional injections pentostam
cryotherapy/heat therapy
topical paromomycin
systemic treatment of cutanouse
glucantime, amphotericin B, mitlefosis( oral so good)
mucocutaneous
pentavalent antimonials + miltefosine
what species can be nnn cultures
leishmania (sandfly) chagas diease (bug)
IP
1- 4 months
