leishmanias Flashcards

1
Q

agents of cutaneous leishamniasi

A

old word: tropica + major

new world: mexicana l braziliensis

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2
Q

what type of parasite is leishmania

A

protozoa

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3
Q

geographical preliclition of cutaneous leishmania

A

old world- europe, africa, asia

new world- south america

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4
Q

infective form

A

metacyclic promastigotes injected from bite of sandfly

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5
Q

can both sexes transmit the disease

A

just female needs blood to lay eggs

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6
Q

what kind of disease is cutaneous leishmaniasis

A

a zoonose

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7
Q

what kind of disease is visceral L

A

ZOOINOSE

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8
Q

typical characteristics of leishmania chancre

A

painless, non healing, grows over time and has an indurated border

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9
Q

types of old world chancres just list

A
  1. urban anthroponotic type
  2. rural zoonotic type
  3. localised cutaneous type
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10
Q

urban anthroponotic type+ what agent causes it

A

usually single, less inflammation and dry and less severe in comparison to wet type caused by tropica

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11
Q

zoonotic chancre type + agent

A

multiple, most more inflammation and more severe in comparison to dry type caused by major

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12
Q

diffuse cutaneous leishmaniasis

A

lesions do not ulcerate
linked to the competence of the immune system
more severe in comparison to basic types as resistant to treatment

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13
Q

diagnosis of cutaneous

A

skin scrapings + from border of the ulcer!!
method: impression (touch preparations) staining with giemsa- see amastigotes in marcophages

pcr

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14
Q

vector

A

sandfly

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15
Q

what form of the parasite will you find in humans

A

amastigote

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16
Q

which is more severe visceral or cutaneous

A

visceral as its system

17
Q

chicleros ulcer caused by

A

l. mexicana

18
Q

which is more severe old world or new world

A

NEW WORLD

19
Q

culture of leishmania

A

NNN medium 24 degrees for 7 days

20
Q

l. brazielens causes

A

espundia or mucocutaneous leishmaniasis

21
Q

topical treatment of cutanoues

A

intralesional injections pentostam
cryotherapy/heat therapy
topical paromomycin

22
Q

systemic treatment of cutanouse

A

glucantime, amphotericin B, mitlefosis( oral so good)

23
Q

mucocutaneous

A

pentavalent antimonials + miltefosine

24
Q

what species can be nnn cultures

A
leishmania (sandfly)
chagas diease (bug)
25
Q

IP

A

1- 4 months