AFRICAN SLEEPING SICKENSS Flashcards
Vector
tsetse fly
species
t. b rhodiesence
t. b gambiense
distribution
east africa- rhodiescenc
central.west gambiense
which one is more common
gambiense
which one has a chronic course
gambiense
which one is a zoonose
rhodisence + chagas disease
what do we call the disease in animals
nagana
who can transmit the infection
tse tse (f+m)
stages of african sleeping
- cutanouse
- hemolymphatic stage
- Cns stage
what manifest in cutaneous stage
a chancre at the site, painful red , seen usually with rhodisecne
winterbottom’s sign
gambiense, posterior cervical ln painless
which african has more lymphadenopathy
gambiense
forms of parasite african and where found
- trypomastigote - bloodm lymph, organs
2. epimastigote - salivary glands of vector
diagnosis of african
always need to check csf to see if spread to decide treatment,
blood - works more rhodes
LN aspirate - gambiense
culture - weinman’s medium
classic tx african
- pentamidine
- eflornithine
- suramin
- melarsoprol
which other disease do we use pentamidine
pneumocystis + visceral leishmaniasis
agent of chagas
t. cruzi
vector
reduviid bug - kissing bug - night time bugs unlike tse tse
IP for chagas disease
1-2 weeks
what forms are found in humans in chagas disease
amastigotes - inside
extracellular - trypomastigotes
how do humans get infected by chagas disease
not by the bite but mythe bug defecting when it feeds
infective form in chagas disease
metacyclic trypomastigotes
classic features of chagas disease
ramonas signs- entry site conjunctiva
chagoma
stages of chagas
acute - usually childhood + self limiting
intermediate - serologic evidence but no physical symptoms
chronic - cardiac and gastrointestinal, megacolon and megaly
diagnosis of chagas
bloods (high parasitemia) in ACUTE
serological - more chronic
thin + thick prepartions
if you did a blood test for chagas disease what would u find
trypomastigotes
treatment of chagas
nifurtimox- high toxicity
benznidazole
but if already chronic drugs cannot reverse
