Lectures 35 and 36 Flashcards
Gamma radiation(is the oxidation agent) and its targets
His / Tyr / Trp
Oxidation (ROS) Agents and Targets
O2-, H2O2, OH radical
Cys and Met
Glycation agent and target
carbonyls (aldehydes and ketones)
Lys / Arg / Cys
nitration agent and target
NO, -ONOO, NO2
Tyr
nitrosylation agent and target
NO, -ONOO, NO2
Cys
Sulfhydration donor and target
H2S –> HS radical
Cys
Succination donor and target
Fumarate
Cys
Phosphorylation donor and target
ATP
Ser / Thr / Tyr
Acetylation donor and target
Acetyl-CoA
Lys / Arg
Methylation donor and target
SAM
Lys / Arg / His
ADP-ribosylation donor and target
NAD+
Arg / Glu / Asp
Glycosylation donor and target
UDP-sugar (CDP-sugar)
N-link: Asn
O-link: Ser / Thr / Tyr
OH-Lys and OH-Pro
Myristoylation donor and target
Myristic-CoA
N-term Gly
Farnesylation donor and target
Farnesyl-PP
Cys
Palmitoylation donor and target
Palmitic-CoA
Cys
Ubiquitination donor and target
Ubiquitin
Lys
Small molecules (purposeful)
phosphorylation, acetylation, methylation, adp-ribosylation, glycosylation
lipid moiety
myristoylation, farnesylation, palmitoylation
small protein
ubiquitination, sumoylation, ISGylation
stochastic small molecule
oxidation, glycation, nitration, nitrosylation, sulfhydration, succination
Nuclear translocation events
O-GlcNacylation
S-nitrosylation
N-acetylation
O-GlcNacylation
Thr 229
S-nitrosylation
Cys-152
N-acetylation
Lys-117, 227, 251
