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Biochem > Lectures 35 and 36 > Flashcards

Lectures 35 and 36 Flashcards

0
Q

Gamma radiation(is the oxidation agent) and its targets

A

His / Tyr / Trp

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1
Q

Oxidation (ROS) Agents and Targets

A

O2-, H2O2, OH radical

Cys and Met

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2
Q

Glycation agent and target

A

carbonyls (aldehydes and ketones)

Lys / Arg / Cys

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3
Q

nitration agent and target

A

NO, -ONOO, NO2

Tyr

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4
Q

nitrosylation agent and target

A

NO, -ONOO, NO2

Cys

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5
Q

Sulfhydration donor and target

A

H2S –> HS radical

Cys

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6
Q

Succination donor and target

A

Fumarate

Cys

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7
Q

Phosphorylation donor and target

A

ATP

Ser / Thr / Tyr

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8
Q

Acetylation donor and target

A

Acetyl-CoA

Lys / Arg

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9
Q

Methylation donor and target

A

SAM

Lys / Arg / His

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10
Q

ADP-ribosylation donor and target

A

NAD+

Arg / Glu / Asp

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11
Q

Glycosylation donor and target

A

UDP-sugar (CDP-sugar)

N-link: Asn
O-link: Ser / Thr / Tyr
OH-Lys and OH-Pro

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12
Q

Myristoylation donor and target

A

Myristic-CoA

N-term Gly

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13
Q

Farnesylation donor and target

A

Farnesyl-PP

Cys

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14
Q

Palmitoylation donor and target

A

Palmitic-CoA

Cys

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15
Q

Ubiquitination donor and target

A

Ubiquitin

Lys

16
Q

Small molecules (purposeful)

A

phosphorylation, acetylation, methylation, adp-ribosylation, glycosylation

17
Q

lipid moiety

A

myristoylation, farnesylation, palmitoylation

18
Q

small protein

A

ubiquitination, sumoylation, ISGylation

19
Q

stochastic small molecule

A

oxidation, glycation, nitration, nitrosylation, sulfhydration, succination

20
Q

Nuclear translocation events

A

O-GlcNacylation
S-nitrosylation
N-acetylation

21
Q

O-GlcNacylation

A

Thr 229

22
Q

S-nitrosylation

A

Cys-152

23
Q

N-acetylation

A

Lys-117, 227, 251

24
Q

Now Loading SC GOT

A

.

25
Q

E1, E2, E3

A

activation event, transfer event, ligation even

all enzymes involved in classic cascade for small molecule modification

Biochem (10 decks)

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