Lecture 33 Integration of Metabolism Flashcards
0
Q
leptin
A
secreted by adipocytes, acts on brain hypothalamus
reports on status of TAGs
1
Q
insulin
A
from B cells in pancreas, released after eating
reports on status of blood glucose
2
Q
What happens if leptin increases?
A
Decrease food intake
3
Q
What happens if leptin decreases?
A
increase food intake
4
Q
appetite stimulators
A
NPY (neuropeptide Y)
AgRP (agouti-related peptide)
5
Q
appetite suppressants
A
POMC neurons
MSH
CCK
GLP1 and GLP2
6
Q
high adipose tissue leads to…
A
RBP4 and resistin –> insulin resistance –> metabolic syndrome –> diabetes
7
Q
what is normal blood glucose range?
A
3.6 - 6.1 mM
8
Q
CCK and GLP 1 origin and target
A
gut derived, brain target
