Lecture 34 Nucleotide Metabolism

Question 0

what is a nucleoside

Answer 0

base, sugar

ex. adeonsine

Question 1

what is a nucleotide

Answer 1

base, sugar, phosphate

Question 2

purines

Answer 2

A, G

big ring

Question 3

pyridimine

Answer 3

C, U, T

small ring

Question 4

purine synthesis committed step

Answer 4

aminate PRPP (phosphoribosyl amine)

IMP is the major intermediate

Question 5

what is PRPP made from

Answer 5

ribose-5-phosphate and ATP

Question 6

what are the 2 major salvage enzymes

Answer 6

hypoxanthine guanine phosphoribsoyl transferase

adenine phosphoribosyl transferase

Question 7

PRPP regulation

Answer 7

high IMP, GMP, AMP inhibits purine synthesis

leads to pyrimidines and histidine

Question 8

pyrimidine synthesis

Answer 8

synthesized before attached to a ribose sugar

carbamoyl phosphate and aspartate catalyzed by ATCase make pyrimidine (committed step)

Question 9

pyrimidine regulation

Answer 9

inhibits: CTP, UMP, purines
favors: ATP, PRPP

Question 10

NAMPT action

Answer 10

puts the nicotinamide back on the ribose sugar to make NMN

Question 11

NMNAT synthesis and action

Answer 11

ATP and NMN combine to make enzyme

enzyme makes the dinucleotide (NAD)