Lecture 31 & 32 AA Metabolism

Question 0

which a.a.’s are strictly ketogenic?

Answer 0

Leu, Lys

Question 1

where does the urea cycle occur?

Answer 1

liver

Question 2

what enzymes does the pancreas make?

Answer 2

chymotrypsin, trypsin, carboxypeptidase

Question 3

what else is required for glutamate’s reaction?

Answer 3

Vitamin B6

Question 4

What is the Rate determining step in heme synthesis

Answer 4

succinyl CoA + glycine –> delta-aminolevulinate

Question 5

What are the 4 enzymes in heme synthesis?

Answer 5

ALA dehydratase
porphobilinogen deaminase
uroporhyrinogen III synthase
uroporphyrinogen decarboxylase

Question 6

acute intermittent porphyria

Answer 6

hepatic, defect in porphobilinogen deaminase

Question 7

congenital erythropoetic porphyria

Answer 7

erythrocyte

defect in uroporphyrinogen III synthase

Question 8

Heme degradation pathway

Answer 8

Heme –> biliverdin –> bilirubin –> bilirubin diglucouronide –> urobilinogen –> to either urobilin or stercobilin

Question 9

sphingosine precursor

Answer 9

serine

Question 10

histamine precursor

Answer 10

histidine

Question 11

thyroxine

Answer 11

tyrosine

Question 12

epinephrine

Answer 12

tyrosine

Question 13

serotonin

Answer 13

tryptophan

Question 14

nicotinamide

Answer 14

tryptophan

Question 15

what is generated from arginine?

Answer 15

NO (vasodilator)

1. endothelial ENOS
2. macrophages INOS
3. nervous tissue NNOS