Lecture: Dermatophytosis Flashcards

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1
Q

anamorph state

Dogs and Cats

A
  • microsporum canis
  • microsporum gypseum
  • trichophyton mentagrophytes
  • microsporum persicolor
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2
Q

anamorph state

horses

A

trychopyton equinum

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3
Q

anamorph state

cattle

A

trichophyton verrucosum

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4
Q

anamorph state

pigs

A

microsporum nanum

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5
Q

M. Canis

Reservoir

A

cats

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6
Q

M. gypseum

reservoir

A

soil

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7
Q

T. mentagrophytes

reservoir

A

rodents, rabbits, pocket pets

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8
Q

Dermatophytosis

Predisposing factors

A
  • lack/decreased grooming
  • presence of microtrauma
  • excessive hydration/maceration
  • warm temp and humidity
  • lack of sun exposure
  • strong cell-mediated immunity
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9
Q

Persians and himalayans

A
  • can be predisposed
  • asymptomatic carriers
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10
Q

Dermatophytosis

CS

A
  • variable
  • absent to moderate pruritus
  • muzzle and feets
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11
Q

alopecia in dermatophytosis

A

can be very well demarcated

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12
Q

Dermatophytosis horses

A

skin lesions around saddle and tack areas

pruritus

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13
Q

Dermatophytosis cattle

CS

A
  • severe scaling crusting
  • pain and pruritus variable
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14
Q

Kerion

A
  • Well circumscribed nodular mass
  • folliculitis to furunculotis
  • face, muzzle, feet
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15
Q

Dermatophytosis

DDX

A
  • parasitic diseases
  • allergies
  • pemphigus foliaceus
  • keratinization defects
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16
Q

Dermatophytosis

DX

A
  • Wood’s lamp exam
  • trichogram evaluation
  • culture with microscopic ID
17
Q

fungal culture

A
  • DTM
    • dermatophytes turn culture red in conjuction with growth
    • comtaminants do this too, but not in conjunction with growth
18
Q

mackenzie technique

A
  • tooth brush entire animal (5 minutes….)
    • place tooth brush in medium
19
Q

Dermatophytosis

TX considerations

A
  • eliminate infection from host
  • prevent dissemination
    • spores can persist in environment for 18 months
  • removal of spores from environment
  • dz is zoonotic
  • healthy animals can self-cure in 12-17 weeks
20
Q

dermatophytosis

Therapeutic options

A
  • systemic therapy
  • topical therapy
  • environmental therapy
  • treat all animals in contact (just like scabies)
21
Q

Dermatophytosis

topical therapy

A
  • ketaconazole
  • miconazole
  • chlorhexidine
  • lyme sulfur

*clipping hair vs not clipping hair

22
Q

dermatophytosis

systemic therapy

A
  • ketaconazole
  • Itraconazole
  • Fluconazole
  • Terbinafine
  • Griseofulvin
23
Q

griseofulvin

A
  • fungistatic
  • cheap
  • eat with fatty meal
  • only effective against dermatophytes (NOT YEAST)
  • Side effects
    • V/GI
    • bone marrow suppresion
    • viruses contraindicated (check FIV, FeLV)
    • teratogenic
24
Q

ketoconazole

A
  • fungistatic
  • take with fatty meal
  • don’t use with H2 antagonists
  • good efficacy against
    • M. canis
    • T. mentagrophytes
    • malassezia
  • Side effects
    • V/diarrhea
    • inc liver enzymes (not assoc with clinical signs)
    • intereferes with cytochrome P450
  • tolerated by dogs
  • probs not great in cats
  • Not in pregnant animals
25
Q

Itraconazole

A
  • fungistatic (low doses)
  • fungicidal (high doses)
  • preferred for feline fungal infections
  • take with fattty meal
  • expensive
  • side effects
    • uncommon
  • not recommended with dogs with vasculitis or preggos
26
Q

fluconazole

A
  • fungistatic
  • broad antimycotic spectrum
  • little hepatic metabolism
  • recommended in patients with liver disease
27
Q

terbinafine

A
  • fungicidal
  • pulse therapy
  • few side effects
  • no P450 stuff
28
Q

environmental decontamination

A
  • Swiffer/vacuum
  • Detergent
  • Bleach
  • Enilconazole

*wash everything twice

29
Q

duration of therapy

A
  • no growth on two sequential weekly cultures
    • finalized after 14 days
  • or 2 negative cultures one month apart
30
Q

Onychomycosis

(infection of the nails)

A
  • prognosis for cure is guarded (tx 6-12 months) if at all
  • Itraconazole and terbinafine are best agents
    • stay in keratinized tissue
31
Q

Large animal therapy

A
  • Infections usually self limiting
  • exposure to sun helps
  • topical therapy
    • lyme sulfur (till 2 weeks past clinical cure)