Lecture 9 - variability due to genetics

Question 1

CYP3A5 marker drug?

Answer 1

tacrolimus

Question 2

CYP3A5 ethnicities?

Answer 2

80% white and 25% africans have non-expressive 3/3 version

Question 3

Purine metabolism - marker drug?

Answer 3

6-mercaptopurine

Question 4

Alcohol/acetaldehyde dehydrogenase - ethicity?

Answer 4

40% asians flush due to excessive acetaldehyde formation

Question 5

Molecule responsible in multi-drug resistance to treatment?

Answer 5

PGP transporter

Question 6

Warfarin sensitivity and resistance?

Answer 6

sensitivity vitK epOxide reductase - lower dose (asians); resistance vitK oxidase - higher dose (superior race)

Question 7

HLA-B?

Answer 7

Phenytoin contraindication with *1502 allele due to adverse skin reactions