Lecture 2 - Volume of Distribution

Question 1

Volume of Distribution definition?

Answer 1

relationship between concentration, and amount of drug in the body

Question 2

Compartments of body?

Answer 2

blood (plasma and RBC), ECM, body water

Question 3

Tissue binding?

Answer 3

tissue proteins (Nz/K ATPase) and other drug receptors (minor contribution)

Question 4

Partitions?

Answer 4

lipophilic drugs (increase V), hydrophilic drugs (no effect on V), bone (absorption)

Question 5

Apparent central compartment volume?

Answer 5

approx. extracellular fluid volume

Question 6

Apparent tissue compartment volume?

Answer 6

depends on tissue binding and partition