Lecture 18 - Clinical Pharmacology and Prescribing Flashcards
Rational prescribing?
selection of most appropriate therapeutic regimen for a specific patient
Treatment goal?
identify key management issue - symptom control vs. disease modification
Criteria for choosing medicine?
efficacy, safety, appropriateness
Efficacy considerations?
supporting evidence, between individual variance
Safety Considerations?
contraindications e.g. allergies, common adverse effects
Appropriateness considerations?
affordability, compliance (twice daily)
4 steps prior to writing a prescription/
make a diagnosis, make a therapeutic decision, choose a medicine, choose a dosing regime
First part of script?
name of medicine, formulation, strength
2nd and 3rd part of script?
instructions for patient and pharmacist respectively
Indication for drug monitoring?
potentially serious event, narrow therapeutic index, effects correlate w blood concentration better than dose, deciding if symptom is adverse effect