Lecture 7 - RAAS

Question 1

Renin?

Answer 1

released as result of SNS activation, catalyses conversion of angiotensinogen into angiotensin I

Question 2

ACE?

Answer 2

located in endothelial cells, converts I into II

Question 3

Angiotensin II?

Answer 3

potent vasoconstrictor via AT-1 receptor

Question 4

Angiotensin III?

Answer 4

promotes aldosterone secretion - thirst, NA reabsorption

Question 5

Angiotensin IV?

Answer 5

inhibition of clot clearance

Question 6

Processes which RAAS acts?

Answer 6

vascular tone, natriuresis (salt retention)

Question 7

Aldosterone and channels?

Answer 7

increases apical Na+ and basolateral Na/K transporters

Question 8

ACE-Is and e.g.?

Answer 8

competitive inhibitors of ACE, lowering angiotensin II e.g. cilazipril

Question 9

Adverse effects of ACE-Is?

Answer 9

dry cough, angioedema

Question 10

ACE-I induced angioedema?

Answer 10

higher levels of bradykinin -> vasodilation and increased permeability

Question 11

ARB example?

Answer 11

losartan

Question 12

ACE-I vs ARB?

Answer 12

ACE-I tend to have greater effect, but hihger risk of adverse effects

Question 13

Ca channel e.g.?

Answer 13

verapamil

Question 14

Diuretics?

Answer 14

counter Angio. II action, increase Na excretion, variety of renal tubule targets

Question 15

Diuretic e.g.?

Answer 15

amiloride

Question 16

Beta blockers and RAAS?

Answer 16

decrease cardiac contractility, decrease renin secretion

Question 17

Beta blocker e.g.?

Answer 17

metoprolol