Lecture 1 - Clearance Flashcards
1
Q
Clearance Definition?
A
the relationship between concentration and the rate of elimination of a drug from the body
2
Q
Maintenance dose rate?
A
at steady state, rate in = rate out; therefore, rate out = clearance x concentration
3
Q
Organ upper limits or clearance?
A
90L/h for liver, 70L/h for kidney
4
Q
Clearance classifications?
A
constant, concentration dependent, flow dependent
5
Q
Concentration dependent clearance - calculations?
A
CL.C (first order, drug concentration is negligible), [Vmax/Km + C].c (mixed order), Vmax (zero order, Km is negligible)
