Lecture 17 - Target Concentration Intervention

Question 1

Target Concentration formula?

Answer 1

Target Conc. = Target effect x C50 / (Emax - target effect) - individual estimates

Question 2

Why does PKPD vary?

Answer 2

systemic (body size, disease, genotype) and random (between and within individual variability

Question 3

Dosing categorization?

Answer 3

Population (same dose - adults), Group (same dose for similar group e.g. children), individual (dose determined by individual response

Question 4

2 criterion for TCI?

Answer 4

usefulness is hard to measure from clinical outcome, and big unpredictable variability but with small within individual variability

Question 5

Target Concentration Study?

Answer 5

Choose target conc., determine V and CL, calculate LD and MDR, measure response, measure conc, repeat step 3 (LD)

Question 6

Timing of sample?

Answer 6

as soon as possible, in middle of sampling interval

Question 7

TDM

Answer 7

therapeutic drug monitoring, jsut aiming between ineffective and toxic, sub-optimal at borders of range