Lecture 9: Neuropeptides Flashcards
1
Q
How are NP taken back into terminals?
A
There’s no current evidence that reuptake happens. Only metabolised.
2
Q
How are NP’s synthesized?
A
DNA mRNA pre-propeptide propeptide peptide
3
Q
Substance P is a primary NT where?
A
Spine
4
Q
How fast acting are NP’S?
A
Slow (sec - min)
5
Q
What are 2 types of NP’s?
A
Tachykinins
Opioid peptides
6
Q
What type of NP is subs. P?
A
Tachykinin
7
Q
What are 3 types of opioid peptides?
A
Enkephalins
Endorphins
Dynorphins
8
Q
Enkephalins result in what actions?
A
Motor output
Pain sensation
9
Q
Endorphins result in what actions?
A
neuroendocrine control
10
Q
Dynorphins result in what actions?
A
Pain/inflamm response
Learning
11
Q
How are NP’s released?
A
Ca dependent vesicles
12
Q
What are the 3 receptors for NP’s?
A
Mu
Delta
Kappa
