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Medsci 307 > Lecture 6: Dopamine > Flashcards

Lecture 6: Dopamine Flashcards

1
Q

Dopamine comes from which molecule?

A

Tyrosine

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2
Q

Release of Dopamine?

A

Ca dependent

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3
Q

Inactivation of Dopamine?

A

Reuptake via transporter or vesicles

Metabolised via MAO and COMT to be HVA

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4
Q

3 paths of dopamine?

A
  1. Nigrostriatal (SNc to striatum)
  2. Mesolimbic/Mesocortical (midbrain to ventral striatum, limbic system and cortex)
  3. Hypothalamic (neuroendocrine control)
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5
Q

Receptors of dopamine?

A

D1-5
D1 - cAMP elevation
D2 - cAMP reduction

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6
Q

Functions of Dopamine?

A

neuromodulatory
motor control
mood
reward

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7
Q

What happens in cocaine addiction?

A

Increase of dopamine in synaptic cleft in nucleus accumbens. High, dependence.

D1 agonists increase cocain seeking behaviour
D2 agonists decrease craving

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Medsci 307 (10 decks)

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