Lecture 5: NA/Serotonin

Question 1

NA created from what?

Answer 1

Tyrosine

Question 2

Enzyme converts Dopamine to NA?

Answer 2

Dopamine B hydroxylase (DBH)

Question 3

Where is DBH found?

Answer 3

only in NA neurons (so can be used as a marker)

Question 4

How is NA released?

Answer 4

Ca dependent

Question 5

How is NA inactivated?

Answer 5

Reuptake via transporter

Metabolism via COMT (extracell) and MAO (mitochon)

Question 6

Pathway of NA?

Answer 6

Locus Ceruleus (brainstem)

Question 7

NA function?

Answer 7

Sustained affects with K conductance
Sets tone in neurons
BP, thermoreg, pain control

Question 8

Receptors of NA?

Answer 8

a1A, 1B, 2A, 2B

B1,2,3

Question 9

Serotonin (5-hydroxytryptamine) comes from what?

Answer 9

L-tryptophan

Question 10

What converts 5-hydroxytryptophan to serotonin?

Answer 10

L-aromatic acid dexarboxylase

Question 11

Release of Serotonin?

Answer 11

Fusion of vesicle with membrane via Ca

Question 12

Inactivation of 5-HT?

Answer 12

Reuptake - high affinity active transport

Metabolised via MAO to 5-HIAA

Question 13

Location of 5-HT?

Answer 13

Raphe nuclei (brainstem)
--> ascending paths and descending

Question 14

Receptors for 5-HT?

Answer 14

5-HT: 1A, 1B, 1C, 2, 3