Lecture 11: Neuronal Apoptosis Flashcards
1
Q
CED-3 is like what in C. elegans?
A
Caspase
2
Q
What is the death receptor path (extrinsic path) of caspases?
A
Fas ligand Fas receptor FADD DED of FADD + procaspase 8 bind Caspase 8 activated Caspase 3,6,7 activated Death substrates produced Apoptosis
3
Q
What is the mitochondrial path (intrinsic path) of caspases?
A
DNA damage +p53 actication Cyt. C released Apoptosome (cyt. c + Apaf-1 + procaspase 9) caspase 9 active caspase 3,6,7 active death substrate form apoptosis
4
Q
ER path of caspases?
A
Misfolding response caspase 12 activated caspase 9 active caspase 3,6,7 active apoptosis
5
Q
What are 5 caspase substrates?
A
PARP ICAD Lamins Fodrin + actin Caspase 8
6
Q
Evidence of caspase-independent apoptosis?
A
Z-VAD is caspase inhibitor, and in presence, apoptosis still occurred.
7
Q
Anti-apoptotic molecule in death receptor path AND mitoch. path?
A
Death receptor: FLIP
Mitoch: Bcl-2, Bcl-XI
8
Q
3 endogenous caspase inhibitors?
A
XIAP
NIAP
CIAP-1
