Lecture 4: Basal Ganglia Flashcards
Corticostriate path has what transmitter?
Glutamate
Striatopallidal has what transmitter?
GABA/Enk
What is the striatopallidal path?
Putamen
GP Externa
SUT
GP Interna
Which path is the direct path?
Striatopallidal/Striatonigral
What is the neurotransmitter for the direct path?
GABA/Sub P
What is the neurotransmitter for the indirect path?
GABA/Enk
What is the indirect path?
Striatopallidal
Transmitter for nigrostriatal?
Dopamine
What dopamine receptor is excitatory?
D1
Where do D1 and D2 transmit to?
SNc (pars compacta)
Basal ganglia outputs to VA-VL originate from where?
GP Interna
SNr
Exciting the direct pathway (Striatopallidal/Striatonigral) results in….
Movement
Exciting the indirect pathway (striatopallidal) results in…
Less movement
Dopamine acts on what receptors in the direct path? What does this result in?
D1 More movement (turning on direct path)
Dopamine acts on what receptors in the indirect path? What does this result in?
D2 More movement (turning off indirect path)
Huntington’s is on what chromosome?
4 (short arm)
What main movement symptom results (both direct and indirect) from HD? How?
Hyperkinesia (indirect) - less inhibition
Hypokinesia (direct) - over inhibition
Loss of GABAergic neurons (less inhibition) and less Enk
Parkinson’s disease is from the loss of what cells?
Dopamine cells
Two symptoms of PD
Hypokinesia (Direct)
Bradykinesia (Indirect)
