Lecture 4: Basal Ganglia

Question 1

Corticostriate path has what transmitter?

Answer 1

Glutamate

Question 2

Striatopallidal has what transmitter?

Answer 2

GABA/Enk

Question 3

What is the striatopallidal path?

Answer 3

Putamen
GP Externa
SUT
GP Interna

Question 4

Which path is the direct path?

Answer 4

Striatopallidal/Striatonigral

Question 5

What is the neurotransmitter for the direct path?

Answer 5

GABA/Sub P

Question 6

What is the neurotransmitter for the indirect path?

Answer 6

GABA/Enk

Question 7

What is the indirect path?

Answer 7

Striatopallidal

Question 8

Transmitter for nigrostriatal?

Answer 8

Dopamine

Question 9

What dopamine receptor is excitatory?

Answer 9

D1

Question 10

Where do D1 and D2 transmit to?

Answer 10

SNc (pars compacta)

Question 11

Basal ganglia outputs to VA-VL originate from where?

Answer 11

GP Interna

SNr

Question 12

Exciting the direct pathway (Striatopallidal/Striatonigral) results in….

Answer 12

Movement

Question 13

Exciting the indirect pathway (striatopallidal) results in…

Answer 13

Less movement

Question 14

Dopamine acts on what receptors in the direct path? What does this result in?

Answer 14

D1
More movement (turning on direct path)

Question 15

Dopamine acts on what receptors in the indirect path? What does this result in?

Answer 15

D2
More movement (turning off indirect path)

Question 16

Huntington’s is on what chromosome?

Answer 16

4 (short arm)

Question 17

What main movement symptom results (both direct and indirect) from HD? How?

Answer 17

Hyperkinesia (indirect) - less inhibition
Hypokinesia (direct) - over inhibition
Loss of GABAergic neurons (less inhibition) and less Enk

Question 18

Parkinson’s disease is from the loss of what cells?

Answer 18

Dopamine cells

Question 19

Two symptoms of PD

Answer 19

Hypokinesia (Direct)

Bradykinesia (Indirect)