Lecture 10: ACh and NGF

Question 1

How is ACh made?

Answer 1

Acetate + co-enzyme A
Acetyl-CoA + Choline
ACh

Question 2

Choline acetyltransferase does what?

Answer 2

Acetyl CoA + Choline -> ACh

Question 3

How is ACh inactivated?

Answer 3

ACh -> Acetate + choline

Question 4

Which muscarinic receptors are Gq linked?

Answer 4

M1,3,5 (incr. in IP3/DAG)

Question 5

Which muscarinic receptors are Gi linked?

Answer 5

M2,4 (stops adenylate cyclase)

Question 6

Antagonist of ACh in muscarinic receptor?

Answer 6

Atropine

Question 7

Antagonist of nicotinic receptor?

Answer 7

Bungarotoxin

Question 8

Which 2 paths are lost in AD?

Answer 8

Basal nucleus of Myenert

Medial Septum

Question 9

Muscarinic antagonists are anti-vomiting, also known as?

Answer 9

anti-emetic

Question 10

Which characteristic EEG wave is seen in hippocampus?

Answer 10

Theta rhythm (medial septal activation of M1 receptors)

Question 11

Where is NGF secreted from?

Answer 11

Hippocampal neurons

Question 12

What does NGF do?

Answer 12

Maintains cholinergic phenotype of medial septal neurons

Question 13

What is NGF bound to?

Answer 13

p75

Question 14

Where is NGF transported to?

Answer 14

to Medial septum, retrogradely.

Question 15

What does NGF affect?

Answer 15

Tyrosine Kinase A receptor

Question 16

What does TrkA receptor do?

Answer 16

Mediates effect of NGF on medial septal neurons